Product image of Metamizol Tad (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Tad

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Tad (Metamizole Sodium Monohydrate)

Metamizole Sodium Monohydrate, the active ingredient in Metamizol Tad, is a pyrazolone presented as a parenteral solution for intramuscular and intravenous use. It provides analgesic and antipyretic effects for adults experiencing pain or fever, including postoperative discomfort and visceral colic.

GNH India supplies Metamizol Tad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows EU‑quality standards and offers reliable global distribution.

Manufacturer / TM Owner

Tad Pharma Gmbh

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Indications & Clinical Uses

  • Metamizole is employed to manage pain and fever across several clinical settings.
  • Pain: provides relief of moderate to severe acute pain
  • Fever: reduces elevated body temperature in febrile patients
  • Postoperative pain: controls pain following surgical procedures
  • Colic: alleviates visceral pain associated with intestinal colic

How It Works

  • Metamizole inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis, and also modulates endogenous opioid pathways. The combined reduction of prostaglandin‑mediated inflammation and activation of opioid‑related analgesic mechanisms underlies its analgesic and antipyretic activity, although the precise pharmacodynamic profile is not fully elucidated.

Side Effects

Metamizole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hypotension: transient drop in blood pressure after injection
  • Nausea: mild to moderate feeling of queasiness
  • Vomiting: occasional emesis following administration
  • Injection site reactions: pain, redness or swelling at the site

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells
  • Anaphylaxis: life‑threatening allergic reaction
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder
  • Hepatic dysfunction: abnormal liver enzyme elevations

Precautions & Warnings

  • Before using Metamizol Tad, consider the following precautions.
  • Assess renal function: adjust use in patients with renal impairment
  • Monitor blood counts: watch for signs of agranulocytosis
  • Use cautiously in hepatic disease: avoid in severe liver dysfunction
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs
  • Do not combine with other myelosuppressive agents: increased risk of blood disorders
  • Store at ambient temperature: keep in original packaging, protect from moisture and light

Avoid Interactions

Metamizol Tad can interact with several drug classes; awareness of these interactions helps minimize risk.

Major Interactions (Avoid)

  • Concurrent myelosuppressive drugs: may amplify risk of agranulocytosis
  • Other NSAIDs: increase gastrointestinal bleeding potential
  • Drugs causing agranulocytosis (e.g., carbamazepine): heightened hematologic risk
  • Anticoagulants: may enhance bleeding tendency

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect
  • Diuretics: possible electrolyte disturbances
  • CYP‑metabolized drugs: may alter plasma concentrations of co‑administered agents

Frequently Asked Questions

Metamizol Tad contains the pyrazolone analgesic Metamizole and is prescribed to relieve moderate to severe pain and to reduce fever. It is commonly used after surgery, for acute visceral pain such as colic, and in other situations where rapid analgesic and antipyretic effects are needed.

Metamizole works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production and reduces inflammation‑related pain. It also influences endogenous opioid pathways, enhancing pain‑modulating signals in the central nervous system. Together, these actions provide both analgesic and antipyretic effects.

The exact dose of Metamizol Tad is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Dosing is individualized and administered by a healthcare professional via intramuscular or intravenous injection.

Safety data for Metamizole in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and only under close medical supervision.

To place an order, submit an enquiry on the Metamizol Tad product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Metamizole offers rapid analgesic and antipyretic effects similar to non‑steroidal anti‑inflammatory drugs (NSAIDs) but is often chosen when NSAIDs are contraindicated or when a stronger pain relief is required. Unlike opioids, it does not act on µ‑receptors, reducing the risk of typical opioid‑related side effects, though it carries a unique risk of agranulocytosis.

Store Metamizol Tad at ambient temperature, preferably below 25 °C. Keep the vials in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly sealed when not in use.

Metamizol Tad is supplied as a sterile injectable solution and must be administered by a qualified healthcare professional. It can be given either intramuscularly or intravenously, depending on the clinical situation and the prescriber’s recommendation.

The most serious adverse events include agranulocytosis, which can lead to severe infections, and life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical attention is required if patients develop signs of infection, unexplained fever, skin rash, or breathing difficulties.

Metamizol Tad should be avoided in individuals with known hypersensitivity to Metamizole or other pyrazolones, in patients with severe hepatic impairment, and in those who have previously experienced agranulocytosis. Caution is also advised for patients with uncontrolled hypertension or active bleeding disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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