Product image of Metamizol Tarbis (Metamizole Magnesium) supplied by GNH India

Metamizol Tarbis

Active Ingredient:
Metamizole Magnesium
Origin:
EU

Metamizol Tarbis (Metamizole Magnesium)

Metamizole, the active ingredient in Metamizol Tarbis, is a pyrazolone analgesic presented as an oral formulation for oral use. It treats acute and post‑operative pain, fever, and visceral colic in adult patients.

GNH India supplies Metamizol Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Metamizole is used to manage pain and fever by inhibiting prostaglandin synthesis.

  • Acute pain: provides rapid relief of moderate to severe pain.
  • Post‑operative pain: reduces pain intensity after surgical procedures.
  • Fever: lowers elevated body temperature in febrile states.
  • Colic and visceral pain: alleviates spasm‑related abdominal discomfort.

How It Works

  • Metamizole magnesium acts by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain and fever pathways. It also exerts central analgesic effects through modulation of spinal pain transmission, contributing to its antipyretic and analgesic properties.

Side Effects

Metamizole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness
  • Headache
  • Skin rash
  • Mild hypotension

Serious or Rare Side Effects

  • Agranulocytosis (dangerous drop in white blood cells)
  • Anaphylactic reactions
  • Stevens‑Johnson syndrome
  • Severe blood dyscrasias
  • Hepatotoxicity
  • Acute kidney injury

Precautions & Warnings

Use Metamizole with caution and observe the following precautions.

  • Renal impairment: assess kidney function before initiating therapy.
  • Hepatic disease: monitor liver enzymes during treatment.
  • History of blood disorders: avoid or closely monitor blood counts.
  • Concomitant NSAIDs: increased risk of gastrointestinal bleeding.
  • Pregnancy: safety unknown; avoid unless clearly needed.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metamizole can interact with other medicines; consider the interactions below.

Major Interactions (Avoid)

  • Cytotoxic chemotherapy agents: heightened bone‑marrow suppression risk.
  • Anticoagulants (e.g., warfarin): may increase bleeding tendency.
  • Sulfonamide antibiotics: potential cross‑reactivity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive effects.
  • Diuretics: possible alteration of renal function.
  • Lithium: risk of elevated lithium concentrations.

Frequently Asked Questions

Metamizol Tarbis contains the pyrazolone analgesic metamizole and is indicated for the relief of moderate to severe acute pain, post‑operative pain, high fever, and visceral or colicky pain. It is prescribed for adult patients when rapid analgesic and antipyretic effects are required.

Metamizole inhibits cyclooxygenase enzymes, which reduces the production of prostaglandins that mediate pain and fever. In addition, it influences central pain pathways in the spinal cord, providing a combined peripheral and central analgesic effect that also lowers body temperature.

The specific dose of Metamizol Tarbis is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual health factors. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed for safety and efficacy.

Safety data for metamizole in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Therefore, it should only be used when the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To request Metamizol Tarbis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metamizole offers rapid analgesic and antipyretic effects similar to non‑steroidal anti‑inflammatory drugs (NSAIDs) but with a different chemical class. Unlike opioids, it does not act on opioid receptors, reducing the risk of dependence, but it carries a rare risk of severe blood disorders that are not typical of standard NSAIDs.

Metamizol Tarbis should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Metamizol Tarbis is administered orally. The tablets or oral formulation should be swallowed whole with a full glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any accompanying fluids.

The most serious adverse reactions include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic responses such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be advised to seek immediate medical attention if they develop signs of infection, rash, or breathing difficulties.

Metamizol Tarbis should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, those with a history of severe blood dyscrasias, and patients with significant renal or hepatic impairment unless closely monitored. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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