Metamizol Aiko Farmacéutica (Metamizole Magnesium)

Metamizol Aiko is a non‑opioid analgesic used to treat conditions that involve pain or elevated body temperature.

• Acute pain: provides rapid analgesia for severe acute pain episodes.
• Post‑operative pain: helps control pain after surgical procedures.
• Fever: reduces elevated body temperature in adults.
• Renal colic: alleviates pain associated with kidney‑stone related colic.

• Metamizole magnesium inhibits cyclooxygenase‑mediated prostaglandin synthesis, which reduces the formation of pain‑ and fever‑inducing mediators. Although the exact pathway is not fully defined, the drug’s effect on prostaglandin levels leads to decreased peripheral sensitization and central fever signaling, resulting in analgesic and antipyretic actions.

Metamizol Aiko may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Dizziness: transient light‑headedness.
• Skin rash: mild erythema or itching.
• Headache: occasional tension‑type headache.

Serious or Rare Side Effects

• Agranulocytosis: severe drop in white blood cells, requiring immediate medical attention.
• Aplastic anemia: bone‑marrow failure leading to pancytopenia.
• Stevens‑Johnson syndrome: severe skin and mucosal reaction.
• Hepatic injury: rare liver enzyme elevation.
• Severe hypotension: abrupt drop in blood pressure.

Before prescribing Metamizol Aiko, clinicians should consider several safety aspects.

• Renal function: monitor in patients with impaired kidney function.
• Hepatic function: use caution in liver disease.
• Allergy: avoid if known hypersensitivity to pyrazolones.
• Blood disorders: discontinue if signs of agranulocytosis appear.
• Pregnancy: safety not established; avoid unless essential.
• Store at ambient temperature: keep in the original container, protect from moisture and light.

Metamizol Aiko can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Myelosuppressive agents: increased risk of agranulocytosis.
• Anticoagulants: may enhance bleeding tendency.
• ACE inhibitors: can potentiate hypotensive effects.

Moderate Interactions (Monitor Closely)

• NSAIDs: additive gastrointestinal irritation.
• Cimetidine: may raise plasma levels of metamizole.
• Alcohol: can increase sedation and dizziness.