Product image of Metamizole Sodium Bausch Health (Metamizole Sodium) supplied by GNH India

Metamizole Sodium Bausch Health

Active Ingredient:
Metamizole Sodium
Origin:
EU

Metamizole Sodium Bausch Health (Metamizole Sodium)

Metamizole Sodium, the active ingredient in Metamizole Sodium Bausch Health, is a non‑opioid analgesic (pyrazolone) presented as an injectable solution for intramuscular or intravenous use. It is employed to manage acute moderate to severe pain, postoperative discomfort, fever, and visceral colic in adult patients.

GNH India supplies Metamizole Sodium Bausch Health as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

  • Metamizole Sodium is indicated for conditions involving pain and fever where rapid relief is required.
  • Acute moderate to severe pain: provides analgesia for sudden, intense pain episodes.
  • Post‑operative pain: reduces discomfort following surgical procedures.
  • Fever: lowers elevated body temperature associated with infection or inflammation.
  • Colic and visceral pain: alleviates spasm‑related abdominal pain.

How It Works

  • Metamizole Sodium inhibits cyclooxygenase‑mediated prostaglandin synthesis, reducing inflammatory mediators, and simultaneously modulates endogenous opioid pathways, enhancing analgesic and antipyretic effects without engaging opioid receptors.

Side Effects

Metamizole Sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypotension: transient drop in blood pressure after injection.
  • Dizziness or vertigo.
  • Nausea or vomiting.
  • Injection‑site pain or erythema.
  • Mild leukopenia: slight reduction in white blood cells.

Serious or Rare Side Effects

  • Agranulocytosis: severe depletion of neutrophils, potentially life‑threatening.
  • Severe allergic reactions: anaphylaxis, bronchospasm.
  • Skin disorders: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated liver enzymes.
  • Hemolytic anemia.
  • Renal impairment: acute kidney injury.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient history and monitor relevant parameters.
  • Assess for blood dyscrasias: perform baseline and periodic complete blood counts.
  • Monitor renal and hepatic function: adjust use if impairment is detected.
  • Use caution in patients with hypertension or cardiovascular instability.
  • Avoid in individuals with known hypersensitivity to pyrazolones.
  • Administer under medical supervision: ensure appropriate monitoring during and after injection.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct light.

Avoid Interactions

Metamizole Sodium can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other myelosuppressive agents: heightened risk of severe blood cell depletion.
  • Drugs known to cause agranulocytosis (e.g., carbamazepine): additive risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): potential additive renal effects.
  • Diuretics: may exacerbate hypotension.
  • Corticosteroids: increased risk of gastrointestinal irritation.
  • ACE inhibitors: possible enhancement of hypotensive response.

Frequently Asked Questions

Metamizole Sodium is employed as a non‑opioid analgesic and antipyretic. It provides rapid relief for acute moderate to severe pain, postoperative discomfort, high fever, and visceral colic. The drug is administered by intramuscular or intravenous injection under medical supervision.

The compound blocks cyclooxygenase enzymes, lowering prostaglandin production that mediates pain and fever. In addition, it influences endogenous opioid pathways, enhancing analgesic effects without directly activating opioid receptors, resulting in combined pain‑relieving and temperature‑reducing actions.

Dosing is individualized by the prescribing clinician based on the patient’s condition, weight, and response. The medication is supplied for intramuscular or intravenous injection, and the prescriber determines the exact amount, frequency, and duration of therapy.

Safety data for Metamizole Sodium in pregnancy and lactation are limited, and the pregnancy category is unknown. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and only under professional guidance.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs), and necessary import documentation.

Compared with traditional NSAIDs, Metamizole Sodium offers strong analgesia and antipyresis with a lower risk of gastrointestinal irritation but carries a unique risk of blood dyscrasias such as agranulocytosis. Unlike opioids, it does not cause respiratory depression, making it a useful alternative for certain acute pain scenarios.

The injectable product should be stored at ambient temperature, below 25 °C, in its original container. Protect it from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze; inspect the solution for particulate matter before administration.

Metamizole Sodium is given by a healthcare professional via intramuscular or intravenous injection. The route, injection site, and rate of infusion are selected according to the clinical situation and the prescriber’s instructions.

The most critical adverse events include agranulocytosis, which can lead to severe infection, and life‑threatening allergic reactions such as anaphylaxis. Monitoring blood counts and observing for signs of infection or hypersensitivity are essential during therapy.

Patients with known hypersensitivity to Metamizole Sodium or other pyrazolones, those with existing blood dyscrasias, severe hepatic or renal impairment, and individuals with uncontrolled hypertension should avoid this medication. A thorough medical assessment is required before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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