Product image of Metamizolnatrij Hidrat Bausch Health (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizolnatrij Hidrat Bausch Health

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizolnatrij Hidrat Bausch Health (Metamizole Sodium Monohydrate)

Metamizole Sodium Monohydrate, the active ingredient in Metamizolnatrij Hidrat, is a pyrazolone derivative presented as an oral dosage form for oral use. It is employed to relieve pain and reduce fever in adult patients.

GNH India supplies Metamizolnatrij Hidrat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured batches and regulatory compliance for global distribution. The company adheres to EU GMP standards and provides full documentation for importers, with customer support that includes technical assistance and timely shipment tracking.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Metamizole Sodium Monohydrate is used for analgesic and antipyretic therapy in conditions requiring pain relief or fever reduction.

  • Pain: provides effective analgesia for moderate to severe acute pain.
  • Fever: reduces elevated body temperature in febrile states.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Cancer‑related pain: may be used as part of multimodal analgesia for cancer patients.

How It Works

  • Metamizole Sodium Monohydrate exerts its effect by non‑selective inhibition of cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis, and by modulating central pain pathways through interaction with spinal and supraspinal receptors. The drug also influences the endogenous opioid system and may affect cytokine release, contributing to its antipyretic properties.

Side Effects

Metamizole Sodium Monohydrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Vomiting: occasional episodes.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythema.
  • Hypotension: transient drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction of white blood cells.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Hepatotoxicity: liver enzyme elevation or injury.
  • Blood dyscrasias: including thrombocytopenia or hemolytic anemia.

Precautions & Warnings

When prescribing Metamizole Sodium Monohydrate, clinicians should consider several safety precautions.

  • Renal impairment: use with caution in patients with reduced kidney function.
  • Hepatic disease: monitor liver function tests during therapy.
  • History of blood disorders: avoid in patients with prior agranulocytosis or leukopenia.
  • Concomitant immunosuppressants: increase risk of infection.
  • Elderly patients: start at lower doses and monitor for adverse effects.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole Sodium Monohydrate can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Methotrexate: enhanced toxicity due to reduced renal clearance.
  • Cyclosporine: possible nephrotoxicity augmentation.
  • Lithium: may increase serum lithium levels.
  • ACE inhibitors: risk of additive hypotension.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • SSRIs or SNRIs: potential for increased bleeding.
  • Diuretics: may enhance hypotensive effect.
  • Antihypertensives: may require dose adjustment.
  • Oral contraceptives: possible reduction in efficacy.

Frequently Asked Questions

Metamizolnatrij Hidrat contains Metamizole Sodium Monohydrate, which is prescribed to relieve moderate to severe pain and to lower elevated body temperature. It is commonly used in acute pain scenarios, postoperative settings, and febrile conditions where rapid antipyretic action is needed.

The drug works by non‑selectively inhibiting cyclooxygenase enzymes, reducing prostaglandin production, and by modulating central pain pathways in the spinal cord and brain. These actions together provide analgesic and antipyretic effects, while also influencing opioid and cytokine pathways.

The appropriate dose of Metamizole Sodium Monohydrate is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, and renal or hepatic function. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Metamizole Sodium Monohydrate in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. It should only be used during pregnancy or while breastfeeding if the potential benefit justifies the potential risk, and under close medical supervision.

To order Metamizolnatrij, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metamizole belongs to the pyrazolone class and offers strong analgesic and antipyretic effects, often comparable to high‑dose NSAIDs but with a different safety profile. Unlike opioids, it does not act on opioid receptors, and unlike some NSAIDs, it may have a lower risk of gastrointestinal ulceration but carries a rare risk of agranulocytosis.

Metamizole should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity to maintain stability.

Metamizole Sodium Monohydrate is administered orally, typically as tablets or oral solution, according to the prescriber’s directions. The medication should be swallowed with water and taken with or without food as advised by the healthcare professional.

The most serious adverse reactions include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic responses such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be instructed to seek immediate medical attention if they develop signs of infection, rash, or breathing difficulties.

Metamizole is contraindicated in individuals with a known hypersensitivity to pyrazolones, a history of agranulocytosis or other severe blood dyscrasias, and in patients with severe hepatic or renal impairment unless closely monitored. It should also be avoided in children unless specifically prescribed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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