Product image of Metamizolnatrij Hidrat Kalceks (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizolnatrij Hidrat Kalceks

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizolnatrij Hidrat Kalceks (Metamizole Sodium Monohydrate)

Metamizole Sodium Monohydrate, the active ingredient in Metamizolnatrij Hidrat Kalceks, is a pyrazolone non‑opioid analgesic presented as a sterile solution for intramuscular and intravenous use. It provides analgesic and antipyretic effects for patients with acute moderate to severe pain, postoperative pain, colic, visceral pain, and fever.

GNH India supplies Metamizolnatrij Hidrat Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

  • Metamizole Sodium Monohydrate is used for pain and fever management across several clinical situations.
  • Acute moderate to severe pain: rapid relief of intense nociceptive pain.
  • Post‑operative pain: reduction of discomfort after surgical procedures.
  • Colic and visceral pain: alleviation of spasm‑related abdominal pain.
  • Fever: effective lowering of elevated body temperature.

How It Works

  • Metamizole Sodium Monohydrate exerts its effect by non‑selective inhibition of cyclooxygenase enzymes, decreasing prostaglandin synthesis. The reduced prostaglandin levels diminish peripheral nociceptor sensitization, while central mechanisms contribute to analgesia and spasmolysis. Its action also involves modulation of the endogenous opioid system, enhancing pain relief without opioid receptor binding.

Side Effects

Metamizole Sodium Monohydrate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Injection site pain: local discomfort after IM/IV administration.
  • Transient hypotension: temporary drop in blood pressure.
  • Mild leukopenia: temporary reduction in white blood cells.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Agranulocytosis: severe depletion of neutrophils, potentially life‑threatening.
  • Anaphylaxis: acute allergic reaction with respiratory compromise.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Blood dyscrasias: rare cases of thrombocytopenia or hemolytic anemia.

Precautions & Warnings

  • When using Metamizole Sodium Monohydrate, clinicians should consider several safety measures.
  • Renal impairment: monitor kidney function and adjust use as needed.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • History of blood disorders: avoid in patients with prior agranulocytosis.
  • Concomitant anticoagulants: increased bleeding risk, monitor coagulation parameters.
  • Pregnancy and lactation: safety not established; avoid unless essential.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metamizole Sodium Monohydrate can interact with other medicines; awareness of the level of interaction is important.

Major Interactions (Avoid)

  • Cytotoxic chemotherapy agents: additive bone‑marrow suppression.
  • Sulfonamide antibiotics: increased risk of agranulocytosis.
  • Immunosuppressants: heightened infection risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect, monitor INR.
  • ACE inhibitors: possible additive hypotensive effect.
  • Diuretics: monitor electrolyte balance.

Frequently Asked Questions

Metamizolnatrij Hidrat Kalceks contains Metamizole Sodium Monohydrate, which is employed to relieve acute moderate to severe pain, postoperative discomfort, colic or visceral pain, and to reduce fever in adult patients when other treatments are insufficient.

The compound acts by non‑selectively inhibiting cyclooxygenase enzymes, leading to lower prostaglandin production. This reduces peripheral pain signalling and also provides central analgesic and spasmolytic effects, contributing to its antipyretic action.

Dosing is determined by the prescribing clinician based on the patient’s condition, severity of pain, route of administration, and individual health factors. The prescriber will select the appropriate amount and frequency in accordance with local guidelines.

Safety data for use in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies the potential risk, and under medical supervision.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with opioid analgesics, Metamizole offers effective pain relief without opioid‑related respiratory depression. Unlike NSAIDs, it has a different safety profile, notably a risk of agranulocytosis but a lower incidence of gastrointestinal ulceration. Choice depends on clinical context and patient risk factors.

Metamizole Sodium Monohydrate should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture, direct sunlight and extreme temperatures to maintain stability.

The product is supplied as a sterile injectable solution and can be given either intramuscularly or intravenously by a qualified healthcare professional, following aseptic technique and appropriate dilution if required.

The most serious adverse events include agranulocytosis, which can lead to severe infections, and rare hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical attention is required if signs of these conditions appear.

Patients with a known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis, severe liver or kidney impairment, and individuals for whom safer alternatives are available should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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