Product image of Metaoxedrin Minims Bausch + Lomb Ireland Limited (Phenylephrine Hydrochloride) supplied by GNH India

Metaoxedrin Minims Bausch + Lomb Ireland Limited

Active Ingredient:
Phenylephrine Hydrochloride
Origin:
EU

Metaoxedrin Minims Bausch + Lomb Ireland Limited (Phenylephrine Hydrochloride)

Phenylephrine Hydrochloride, the active ingredient in Metaoxedrin Minims, is a sympathomimetic (alpha‑1 adrenergic agonist) presented as an ophthalmic solution for ocular use. It reduces conjunctival redness and can dilate the pupil to aid eye examinations. It is indicated for the temporary relief of ocular redness associated with minor irritations and is also employed by ophthalmologists to achieve pharmacologic mydriasis during diagnostic procedures.

GNH India supplies Metaoxedrin Minims as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established distribution networks across Europe, Asia and the Americas.

Manufacturer / TM Owner

Bausch + Lomb Ireland Limited

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Indications & Clinical Uses

  • Phenylephrine Hydrochloride ophthalmic solution acts on the ocular vasculature by stimulating alpha‑1 adrenergic receptors, leading to vasoconstriction that relieves redness and produces pupil dilation, making it useful in several ophthalmic situations.
  • Ocular redness: reduces conjunctival hyperemia for temporary cosmetic relief.
  • Conjunctival hyperemia: diminishes vessel engorgement to improve visual comfort.
  • Mydriasis for eye examination: dilates the pupil to facilitate diagnostic procedures.
  • Diagnostic pupil dilation: enables thorough retinal examination.
  • Anterior segment imaging: provides adequate pupil size for photographic documentation.

How It Works

  • Phenylephrine hydrochloride selectively activates alpha‑1 adrenergic receptors on the smooth muscle of conjunctival vessels and the iris dilator muscle. This activation causes vasoconstriction of conjunctival capillaries, reducing redness, and contracts the dilator muscle, leading to pupil enlargement (mydriasis). The combined effect improves ocular clarity for examination and provides temporary relief of hyperemic symptoms.

Side Effects

Common Side Effects

  • Transient burning or stinging sensation in the eye.
  • Mild ocular irritation or itching.
  • Temporary blurred vision after administration.
  • Mild headache.

Serious or Rare Side Effects

  • Significant increase in intraocular pressure.
  • Allergic reactions such as eyelid swelling, rash, or angioedema.
  • Severe ocular pain or photophobia.
  • Systemic hypertension or cardiovascular events.

Precautions & Warnings

  • Phenylephrine ophthalmic solution should be used with caution in the following situations.
  • Contraindicated in narrow‑angle glaucoma: risk of further angle closure.
  • Use with caution in cardiovascular disease: may raise blood pressure.
  • Avoid concurrent use with other mydriatic agents: additive effect.
  • Do not use if hypersensitivity to phenylephrine or any excipients: risk of allergic response.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Phenylephrine ophthalmic solution may interact with other systemic or ocular agents.

Major Interactions (Avoid)

  • MAO inhibitors: may precipitate hypertensive crisis.
  • Systemic sympathomimetics (e.g., pseudoephedrine): additive vasoconstriction.
  • Tricyclic antidepressants: increased cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia.
  • Antihypertensive therapy: phenylephrine may reduce efficacy.
  • Other ocular vasoconstrictors: additive ocular effects.

Frequently Asked Questions

Metaoxedrin Minims is an ophthalmic solution containing phenylephrine hydrochloride. It is used to temporarily relieve ocular redness caused by minor irritations and to produce pharmacologic pupil dilation (mydriasis) during eye examinations or diagnostic procedures.

Phenylephrine hydrochloride selectively stimulates alpha‑1 adrenergic receptors on conjunctival blood vessels and the iris dilator muscle. This causes vasoconstriction, reducing redness, and contracts the dilator muscle, leading to pupil enlargement, which facilitates ocular assessment.

The dosing regimen for Metaoxedrin Minims is determined by the prescribing clinician. Typically, a single drop is instilled in the affected eye(s) as directed, and the frequency is adjusted based on the specific indication and patient response.

Safety data for phenylephrine ophthalmic use in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metaoxedrin Minims (phenylephrine) provides both vasoconstriction and mydriasis, whereas many alternatives such as naphazoline primarily offer vasoconstriction without pupil dilation. Phenylephrine’s dual action makes it useful when both redness relief and pupil enlargement are desired.

Store the ophthalmic solution at room temperature, preferably below 25 °C. Keep the bottle tightly closed, protect it from direct light, and retain it in the original packaging to avoid moisture exposure. Do not freeze the product.

Metaoxedrin Minims is applied topically to the eye. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption.

Serious risks include a marked increase in intraocular pressure, especially in patients with narrow‑angle glaucoma, and systemic hypertension or cardiovascular events due to systemic absorption. Allergic reactions such as eyelid swelling or rash also require immediate medical attention.

Individuals with a known hypersensitivity to phenylephrine or any formulation excipients should avoid the product. It is also contraindicated in patients with narrow‑angle or acute angle‑closure glaucoma, and should be used with caution in those with uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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