Product image of Metaraminol Wockhardt Uk (Metaraminol) supplied by GNH India

Metaraminol Wockhardt Uk

Active Ingredient:
Metaraminol
Origin:
EU

Metaraminol Wockhardt Uk (Metaraminol)

Metaraminol, the active ingredient in Metaraminol Wockhardt Uk, is an alpha‑adrenergic agonist presented as an injectable solution for intravenous use. It is employed to treat acute hypotension, including hypotension that occurs during anesthesia and in septic shock, by rapidly increasing vascular tone and blood pressure.

GNH India supplies Metaraminol Wockhardt Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Wockhardt Uk Ltd

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Indications & Clinical Uses

Metaraminol is a vasopressor used in the management of low‑blood‑pressure states.

  • Acute hypotension: restores systemic blood pressure in patients with sudden drops in arterial pressure.
  • Hypotension during anesthesia: maintains hemodynamic stability throughout surgical procedures.
  • Septic shock: supports circulatory pressure when vasodilatory shock is present.
  • Post‑operative hypotension: helps stabilize patients experiencing blood‑pressure fall after surgery.

How It Works

  • Metaraminol acts as a direct agonist at peripheral alpha‑1 adrenergic receptors, causing smooth‑muscle contraction in arterioles and veins. This vasoconstriction raises systemic vascular resistance and elevates arterial pressure. In addition, Metaraminol promotes the release of endogenous norepinephrine from sympathetic nerve terminals, further enhancing vasomotor tone and supporting blood‑pressure recovery in hypotensive states.

Side Effects

Metaraminol may produce a range of adverse reactions, from mild to severe.

Common Side Effects

  • Tachycardia: rapid heart rate due to reflex sympathetic activation.
  • Headache: pressure changes in cerebral vessels.
  • Nausea: gastrointestinal upset.
  • Sweating: increased sympathetic output.
  • Anxiety: heightened central nervous system stimulation.
  • Palpitations: awareness of irregular heartbeats.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in blood pressure that can endanger organs.
  • Cardiac arrhythmias: abnormal heart rhythms including ventricular tachycardia.
  • Myocardial ischemia: reduced heart‑muscle blood flow leading to chest pain.
  • Tissue necrosis at injection site: local vascular injury from extravasation.
  • Reflex bradycardia: paradoxical slowing of heart rate.
  • Pulmonary edema: fluid accumulation in lungs due to abrupt pressure changes.

Precautions & Warnings

Metaraminol requires careful monitoring and specific safety measures.

  • Blood pressure monitoring: continuously observe arterial pressure to avoid overshoot.
  • Coronary artery disease: use cautiously in patients with known heart‑vascular disease.
  • Bolus administration: avoid rapid large boluses; administer slowly to reduce cardiovascular stress.
  • Renal impairment: adjust dosing and monitor renal function as drug clearance may be affected.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metaraminol can interact with several drug classes, altering its efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Tricyclic antidepressants: additive sympathomimetic effects.
  • Other potent sympathomimetics (e.g., epinephrine): may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt reflex tachycardia.
  • Calcium channel blockers: can enhance hypotensive effects.
  • General anesthetics: may potentiate cardiovascular depression.
  • Diuretics: may exacerbate volume depletion and hypotension.

Frequently Asked Questions

Metaraminol Wockhardt Uk is an injectable vasopressor used to raise blood pressure in patients with acute hypotension, including low pressure that occurs during anesthesia or in septic shock. It works by constricting blood vessels, thereby increasing systemic vascular resistance and supporting circulatory stability.

Metaraminol directly stimulates alpha‑1 adrenergic receptors on vascular smooth muscle, causing vasoconstriction. It also triggers the release of norepinephrine from sympathetic nerve endings, which further amplifies the pressor response and helps restore normal arterial pressure in hypotensive conditions.

The dose of Metaraminol is individualized by the prescribing clinician based on the patient’s condition, severity of hypotension, and response to therapy. Healthcare professionals determine the appropriate infusion rate or bolus amount and adjust it according to continuous blood‑pressure monitoring.

Safety data for Metaraminol in pregnancy and lactation are limited, and the product carries an unknown pregnancy category. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and any required import documentation.

Metaraminol is a direct alpha‑1 agonist with additional norepinephrine‑releasing activity, offering a rapid pressor effect. Compared with agents like norepinephrine, it may produce less tachycardia but can cause reflex bradycardia. Choice of vasopressor depends on the clinical scenario, desired hemodynamic profile, and physician preference.

Metaraminol injectable solution should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial. If the product reaches room temperature, it may be used for a limited period as indicated in the product labeling.

Metaraminol is given intravenously, either as a slow bolus injection or as a continuous infusion. Administration is performed by qualified healthcare personnel in a setting where blood‑pressure and cardiac monitoring are available, allowing rapid adjustment of the dose based on the patient’s response.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, and tissue necrosis if the solution extravasates. Patients should be closely monitored for rapid changes in blood pressure and heart rhythm, and any signs of chest pain, abnormal ECG, or local tissue injury require immediate medical attention.

Metaraminol is contraindicated in patients with known hypersensitivity to the drug or its excipients. Caution is advised in individuals with severe coronary artery disease, uncontrolled hypertension, or those receiving MAO inhibitors, as the combination may precipitate dangerous cardiovascular events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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