Product image of Metatrace (Sodium Fluoride (18f)) supplied by GNH India

Metatrace

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Metatrace (Sodium Fluoride (18f))

Sodium fluoride, the active ingredient in Metatrace, is a fluoride agent presented as an intravenous solution for systemic use. It is employed to correct fluoride deficiency and to support bone mineralization in appropriate clinical contexts. The formulation provides controlled delivery of fluoride ions, allowing rapid restoration of serum fluoride levels under medical supervision.

GNH India supplies Metatrace as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Siemens Healthcare Gmbh

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Indications & Clinical Uses

Metatrace (sodium fluoride) is used in clinical situations that require systemic fluoride supplementation.

  • Fluoride deficiency: restores normal serum fluoride concentrations to support enamel and bone health.
  • Dental caries prevention (adjunct): provides systemic fluoride to enhance enamel resistance when topical measures are insufficient.
  • Metabolic bone disease (selected cases): contributes to bone mineralization under specialist supervision.

How It Works

  • Sodium fluoride dissociates in plasma to release fluoride ions, which replace hydroxide in hydroxyapatite crystals to form fluorapatite, a more acid‑resistant mineral. In bone, fluoride stimulates osteoblastic activity and promotes mineral deposition, while also inhibiting osteoclast‑mediated resorption. The net effect increases tissue fluoride content, enhancing the structural stability of dental enamel and skeletal bone.

Side Effects

Intravenous sodium fluoride may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Injection site pain

Serious or Rare Side Effects

  • Hypocalcemia
  • Cardiac arrhythmia
  • Severe allergic reaction (anaphylaxis)
  • Fluorosis (high‑dose toxicity)

Precautions & Warnings

When using Metatrace, clinicians should observe several precautionary measures to minimize risk.

  • Renal function assessment: evaluate kidney function before and during therapy.
  • Electrolyte monitoring: check serum calcium and phosphate levels regularly.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as safety data are limited.
  • Concomitant calcium supplements: avoid high‑dose calcium products that may reduce fluoride uptake.
  • Drug interactions: review patient medication list for agents that affect fluoride metabolism.
  • Store at below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium fluoride can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Calcium‑containing antacids: reduce fluoride absorption.
  • High‑dose calcium supplements: may precipitate fluoride and diminish effect.
  • Aluminum or magnesium antacids: bind fluoride ions, decreasing bioavailability.
  • Tetracycline antibiotics: form insoluble complexes, lowering effectiveness of both agents.

Moderate Interactions (Monitor Closely)

  • NSAIDs: combined renal stress may increase risk of kidney injury.
  • Loop diuretics: may enhance electrolyte disturbances, especially hypocalcemia.
  • Vitamin D analogues: synergistic effect on calcium metabolism requiring monitoring.
  • ACE inhibitors: potential for altered renal handling of fluoride.

Frequently Asked Questions

Metatrace contains sodium fluoride and is administered intravenously to correct systemic fluoride deficiency and to support mineralisation of bone and dental enamel in patients where oral fluoride is unsuitable or insufficient.

Sodium fluoride dissociates to release fluoride ions that replace hydroxide in hydroxyapatite, forming fluorapatite, which is more resistant to acid dissolution. In bone, fluoride stimulates osteoblast activity and enhances mineral deposition, helping to strengthen skeletal tissue.

The dosage of Metatrace is determined by the prescribing clinician based on the patient’s serum fluoride level, weight, renal function and the specific clinical indication. No fixed regimen is provided in public literature; the prescriber sets the appropriate dose and infusion rate.

Safety data for intravenous sodium fluoride in pregnancy and lactation are limited. It should only be used when the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To request Metatrace, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with oral fluoride tablets or topical gels, intravenous Metatrace delivers fluoride directly into the bloodstream, allowing rapid correction of deficiency and use in patients who cannot tolerate oral formulations. It is not a radiopharmaceutical and is intended for therapeutic, not diagnostic, purposes.

Metatrace should be stored below 25 °C in its original container, protected from light and moisture. The solution must be inspected for particulate matter before use and administered using aseptic technique in a clinical setting.

Metatrace is given by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and total volume are set by the prescriber, and the patient’s vital signs and serum electrolytes are monitored during and after administration.

Serious adverse reactions can include hypocalcemia, cardiac arrhythmias, severe allergic responses such as anaphylaxis, and acute fluoride toxicity (fluorosis) leading to metabolic acidosis or renal impairment. Prompt recognition and management of these events are essential.

Metatrace is contraindicated in patients with known hypersensitivity to fluoride, severe renal impairment, uncontrolled electrolyte disorders, or in those for whom alternative routes of fluoride supplementation are feasible and safer. Clinical judgment should guide exclusion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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