Product image of Metfogamma 1000 (Metformin Hydrochloride) supplied by GNH India

Metfogamma 1000

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metfogamma 1000 (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metfogamma 1000, is a biguanide presented as an oral tablet for oral use. It is used to improve blood glucose control in adults with type 2 diabetes mellitus.

GNH India supplies Metfogamma 1000 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Wörwag Pharma Gmbh & Co. Kg

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Metfogamma 1000, a biguanide antidiabetic, acts on glucose metabolism in type 2 diabetes.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels to improve glycaemic control.

How It Works

  • Metformin Hydrochloride decreases hepatic gluconeogenesis, enhances peripheral glucose uptake, and improves insulin sensitivity by activating AMP‑activated protein kinase (AMPK). This results in reduced glucose production in the liver and increased utilization of glucose by muscle and adipose tissue, helping to lower blood sugar levels.

Side Effects

Metfogamma 1000 may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Loss of appetite: reduced desire to eat.
  • Flatulence: increased gas production.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic acidosis requiring emergency care.
  • Severe hypoglycaemia: especially when combined with other glucose‑lowering agents.
  • Hepatic failure: signs of liver dysfunction.
  • Allergic reactions: rash, itching, or swelling.
  • Pancreatitis: abdominal pain with elevated enzymes.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Metfogamma 1000 should be used with caution in several clinical situations.

  • Renal impairment: assess kidney function before initiating therapy.
  • Hepatic disease: avoid in patients with significant liver dysfunction.
  • Congestive heart failure: monitor for fluid overload and lactic acidosis.
  • Elderly patients: start at lower doses and monitor tolerance.
  • Vitamin B12 deficiency: periodic monitoring recommended.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Metfogamma 1000 can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Iodinated contrast agents: increase risk of lactic acidosis.
  • Cimetidine: may raise metformin plasma concentrations.
  • Other antidiabetic agents that cause hypoglycaemia (e.g., sulfonylureas, insulin): risk of severe low blood sugar.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors and ARBs: monitor renal function and potassium levels.
  • Diuretics: assess for dehydration and renal function.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Corticosteroids: may reduce glycaemic control.
  • Oral contraceptives: possible alteration of metformin clearance.
  • Statins: monitor for rare muscle toxicity.

Frequently Asked Questions

Metfogamma 1000 contains metformin hydrochloride and is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus. It helps lower fasting and post‑prandial glucose levels as part of a comprehensive diabetes management plan.

Metformin works by activating AMP‑activated protein kinase (AMPK), which reduces hepatic glucose production, increases peripheral glucose uptake, and improves insulin sensitivity. These actions collectively lower blood sugar without stimulating insulin secretion.

The dose of Metfogamma 1000 is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made according to professional guidelines and patient monitoring.

The safety of metformin during pregnancy and lactation has not been definitively established. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Metfogamma 1000 belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, and SGLT2 inhibitors in its mechanism of reducing hepatic glucose output rather than stimulating insulin release. It is often chosen for its weight‑neutral profile and low risk of hypoglycaemia when used alone.

Store Metfogamma 1000 at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Metfogamma 1000 is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risks include lactic acidosis, a rare but potentially fatal metabolic complication, and severe hypoglycaemia when combined with other glucose‑lowering agents. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or unusual fatigue occur.

Metfogamma 1000 is contraindicated in patients with known hypersensitivity to metformin, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those with significant hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metformin Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT