Product image of Metfogamma (Metformin Hydrochloride) supplied by GNH India

Metfogamma

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metfogamma (Metformin Hydrochloride)

Metformin, the active ingredient in Metfogamma, is a biguanide presented as an oral tablet for oral administration. It reduces hepatic glucose production and improves peripheral insulin sensitivity, providing glycemic control for adults with type 2 diabetes mellitus.

GNH India supplies Metfogamma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and offering reliable global distribution.

Manufacturer / TM Owner

Wörwag Pharma Gmbh & Co. Kg

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Metfogamma (metformin) is used to manage disorders of glucose metabolism, primarily within the type 2 diabetes therapeutic pathway.

  • Type 2 diabetes mellitus: improves glycemic control by lowering fasting and post‑prandial blood glucose levels.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes when combined with lifestyle measures.
  • Polycystic ovary syndrome (PCOS): may improve insulin resistance and restore ovulatory function in affected women.

How It Works

  • Metformin acts primarily by inhibiting hepatic gluconeogenesis, thereby decreasing endogenous glucose output. It also enhances peripheral glucose uptake in muscle and adipose tissue through activation of AMP‑activated protein kinase (AMPK), which improves insulin sensitivity and reduces intestinal glucose absorption, collectively lowering blood glucose concentrations.

Side Effects

Metfogamma may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient metallic sensation in the mouth.
  • Loss of appetite: reduced desire to eat.
  • Vitamin B12 deficiency: decreased absorption over long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: liver enzyme elevations.
  • Hypoglycemia: when combined with other glucose‑lowering agents.
  • Pancreatitis: inflammation of the pancreas.
  • Anemia: due to reduced red blood cell production.

Precautions & Warnings

Before initiating Metfogamma, clinicians should evaluate patient‑specific risk factors and monitor relevant parameters.

  • Renal function: assess creatinine clearance; avoid in severe renal impairment.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Contrast imaging: discontinue before iodinated contrast procedures to reduce lactic acidosis risk.
  • Alcohol consumption: limit intake as it may potentiate lactic acidosis.
  • Elderly patients: start at lower doses and monitor for gastrointestinal intolerance.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metfogamma can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast media: may precipitate lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): heightened risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • ACE inhibitors or ARBs: can affect renal function, requiring dose adjustment.
  • Diuretics: may increase risk of dehydration and renal impairment.
  • Other oral hypoglycemics: may potentiate hypoglycemia.
  • Warfarin: may require INR monitoring due to potential interaction.

Frequently Asked Questions

Metfogamma contains metformin hydrochloride and is prescribed to lower blood glucose levels in adults with type 2 diabetes mellitus. It may also be used to improve insulin resistance in prediabetes and polycystic ovary syndrome when indicated by a healthcare professional.

Metformin reduces the liver’s production of glucose and increases the sensitivity of muscle and fat cells to insulin. By activating AMP‑activated protein kinase, it enhances glucose uptake and decreases intestinal glucose absorption, resulting in lower blood sugar levels.

The appropriate dose of Metfogamma is determined by the prescribing clinician based on the individual’s medical condition, renal function, and response to therapy. Patients should follow the specific dosing instructions provided by their healthcare provider.

The safety of metformin during pregnancy or lactation should be evaluated by a qualified healthcare professional. While some guidelines allow its use in certain pregnancy situations, the decision must balance potential benefits and risks for both mother and child.

To request Metfogamma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metfogamma (metformin) belongs to the biguanide class and is often first‑line therapy for type 2 diabetes because of its efficacy, low risk of hypoglycemia and favorable impact on weight. Compared with sulfonylureas or insulin, metformin does not cause weight gain and has a well‑established safety profile when used appropriately.

Metfogamma should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain its stability and potency throughout its shelf life.

Metfogamma is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a full glass of water. Patients should not crush or chew the tablets unless specifically instructed by a healthcare professional.

The most serious adverse effect of Metfogamma is lactic acidosis, a rare but potentially fatal condition characterized by the buildup of lactic acid in the blood. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant vitamin B12 deficiency with long‑term use.

Metfogamma is contraindicated in patients with severe renal impairment, known hypersensitivity to metformin, acute or chronic metabolic acidosis, and those receiving iodinated contrast agents for imaging studies. Clinicians should also exercise caution in individuals with liver disease, heart failure or a history of alcohol abuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metformin Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT