Product image of Metfoliquid Geriasan (Metformin Hydrochloride) supplied by GNH India

Metfoliquid Geriasan

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metfoliquid Geriasan (Metformin Hydrochloride)

Metformin, the active ingredient in Metfoliquid Geriasan, is a biguanide presented as an oral formulation for oral use. It is used to lower blood glucose in adults with type 2 diabetes mellitus.
GNH India supplies Metfoliquid Geriasan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Infectopharm Arzneimittel Und Consilium Gmbh, De, Heppenheim

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Indications & Clinical Uses

  • Metformin is indicated for conditions affecting glucose metabolism and insulin sensitivity.
  • Type 2 diabetes mellitus: improves glycaemic control and reduces long‑term complications.
  • Prediabetes (impaired glucose tolerance): helps delay progression to type 2 diabetes.
  • Polycystic ovary syndrome (off‑label): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK), which reduces glucose output. It also enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal glucose absorption, collectively lowering plasma glucose levels.

Side Effects

Metformin is associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Loss of appetite: reduced desire to eat.
  • Upper‑respiratory symptoms: mild cough or sore throat.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hypoglycaemia: uncommon when used alone, more likely with concomitant insulin or sulfonylureas.
  • Acute pancreatitis: rare inflammatory condition of the pancreas.

Precautions & Warnings

Metformin requires careful assessment before and during therapy to minimise risks.

  • Renal function assessment: avoid use if eGFR <30 mL/min/1.73 m².
  • Hepatic impairment: monitor liver enzymes and avoid in severe disease.
  • Lactic acidosis risk: discontinue before major surgery or radiographic contrast studies.
  • Vitamin B12 monitoring: check levels periodically during long‑term therapy.
  • Pregnancy and lactation: evaluate benefit‑risk ratio with the prescriber.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformin may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: increase risk of lactic acidosis; suspend metformin before and after the procedure.
  • Cimetidine: can raise metformin plasma concentrations.
  • Alcohol: potentiates lactic acidosis risk.
  • Certain antiretrovirals (e.g., didanosine): may increase toxicity.
  • Diuretics (loop or thiazide): may impair renal function and raise metformin levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal function and potassium.
  • Warfarin: occasional changes in INR; monitor coagulation.
  • Corticosteroids: may affect glucose control, requiring dose adjustment.

Frequently Asked Questions

Metfoliquid Geriasan contains metformin hydrochloride and is used to improve blood‑glucose control in adults with type 2 diabetes mellitus and to help prevent progression from prediabetes to diabetes.

Metformin activates AMP‑activated protein kinase, which suppresses hepatic glucose production, enhances peripheral insulin‑mediated glucose uptake, and modestly reduces intestinal glucose absorption, thereby lowering overall blood‑sugar levels.

The exact dose and dosing schedule are determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions precisely.

Safety in pregnancy and lactation has not been fully established. The prescriber must weigh potential benefits against risks and decide whether continuation is appropriate for each individual.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is a first‑line oral agent distinguished by its low risk of hypoglycaemia, weight neutrality, and cardiovascular benefit, whereas sulfonylureas often cause weight gain and hypoglycaemia, and newer agents such as SGLT2 inhibitors have different safety profiles.

Store the product at ambient temperature, below 25 °C, in its original packaging. Protect it from moisture, direct sunlight and extreme heat to maintain stability.

Metfoliquid Geriasan is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with water; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition. Other serious concerns include severe skin reactions, hepatic dysfunction, and significant vitamin B12 deficiency with long‑term use.

Patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those undergoing certain radiographic contrast procedures should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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