Product image of Metformax Sr (Metformin Hydrochloride) supplied by GNH India

Metformax Sr

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformax Sr (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformax Sr, is a Biguanide presented as an oral tablet for oral use. It is used to manage type 2 diabetes mellitus in adult patients by decreasing hepatic glucose output and improving peripheral insulin sensitivity, thereby contributing to better glycaemic control.

GNH India supplies Metformax Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable sourcing for healthcare providers through established distribution networks.

Manufacturer / TM Owner

Teva Pharmaceuticals Polska Sp. Z O.O.

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Indications & Clinical Uses

Metformin Hydrochloride is employed in the management of disorders related to glucose metabolism, primarily type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycaemic control by lowering fasting and post‑prandial blood glucose levels.
  • Prediabetes (impaired glucose tolerance): reduces progression to overt diabetes by enhancing insulin sensitivity.
  • Polycystic ovary syndrome (PCOS): helps mitigate insulin resistance, which may improve menstrual regularity and ovulation.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting mitochondrial respiratory‑chain complex I, which decreases hepatic gluconeogenesis. The resulting reduction in hepatic glucose output, together with increased peripheral glucose uptake and enhanced insulin receptor signaling, improves insulin sensitivity in muscle and adipose tissue, leading to lower circulating blood glucose concentrations. It does not stimulate insulin secretion, which minimizes the risk of hypoglycemia when used as monotherapy.

Side Effects

Metformin Hydrochloride may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: loose stools, especially during treatment initiation.
  • Metallic taste: transient alteration in taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic acidosis.
  • Severe hypoglycemia: can occur when combined with insulin or sulfonylureas.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

When prescribing Metformax Sr, clinicians should consider several safety aspects.

  • Renal function: assess creatinine clearance before initiating therapy and monitor periodically.
  • Hepatic function: avoid use in patients with significant liver disease due to lactic acidosis risk.
  • Lactic acidosis risk: discontinue if patient develops unexplained acidosis, severe infection, or hypoxia.
  • Vitamin B12 monitoring: consider periodic testing as long‑term use may reduce B12 levels.
  • Alcohol consumption: advise limiting alcohol as it may increase lactic acidosis risk.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Metformax Sr can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: may raise metformin plasma concentrations, enhancing toxicity.
  • Alcohol: excessive intake heightens risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.

Frequently Asked Questions

Metformax Sr contains metformin hydrochloride and is indicated for the treatment of type 2 diabetes mellitus in adult patients. It helps lower elevated blood glucose by reducing hepatic glucose production and improving insulin sensitivity, supporting overall glycaemic control.

Metformin Hydrochloride primarily inhibits mitochondrial complex I, which suppresses hepatic gluconeogenesis. The drug also enhances peripheral uptake of glucose and improves insulin receptor signaling in muscle and fat tissue, leading to reduced circulating glucose levels without stimulating insulin secretion.

The appropriate dose of Metformax Sr is individualized by the prescribing clinician based on factors such as the patient’s renal function, age, weight, glycaemic targets, and response to therapy. Dosage adjustments are made according to clinical judgment and laboratory monitoring.

Safety data for metformin in pregnancy are limited, and the drug is generally not recommended unless the potential benefit outweighs the risk. It is excreted in breast‑milk, so breastfeeding mothers should discuss alternatives with their healthcare provider.

To order Metformax Sr, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas, metformin (Metformax Sr) does not cause insulin‑mediated hypoglycaemia and promotes modest weight loss. Unlike insulin, it is oral and does not require injection. It is often used as first‑line therapy because of its efficacy, safety profile and cardiovascular benefits.

Metformax Sr should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

Metformax Sr is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

The most serious adverse reactions are lactic acidosis, a rare but potentially fatal condition, and severe hypoglycaemia when metformin is combined with insulin or sulfonylureas. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or unexplained weakness occur.

Metformax Sr is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, and known hypersensitivity to metformin. Caution is also advised in individuals with significant hepatic disease or a history of lactic acidosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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