Metformax Sr 500 (Metformin Hydrochloride)

Metformin reduces hepatic glucose production by inhibiting gluconeogenesis and enhances peripheral insulin sensitivity, which facilitates glucose uptake by muscles and adipose tissue. It also modestly decreases intestinal glucose absorption, leading to lower circulating glucose levels without directly stimulating insulin secretion.

The specific dose of Metformax Sr 500 is determined by the prescribing clinician based on the individual’s medical condition, renal function, and response to therapy. Dosage adjustments are made according to clinical guidelines and patient tolerance, and patients should follow the prescriber’s instructions precisely.

Safety of metformin during pregnancy or lactation is evaluated case by case. While some guidelines allow limited use when benefits outweigh risks, the decision rests with the treating physician. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformax Sr 500 (metformin) belongs to the biguanide class and is often first‑line therapy for type 2 diabetes because of its efficacy, low risk of hypoglycemia, and favorable impact on weight. Compared with sulfonylureas or insulin, metformin does not stimulate insulin release, reducing hypoglycemia risk, but may be combined with other agents when monotherapy is insufficient.

Metformax Sr 500 should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Metformax Sr 500 is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a full glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional and not crush or split the tablet unless instructed.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, heart failure, or excessive alcohol intake. Prompt medical attention is required if symptoms such as unexplained fatigue, rapid breathing, or abdominal pain develop.

Metformax Sr 500 is contraindicated in patients with known hypersensitivity to metformin, severe renal impairment (eGFR <30 mL/min/1.73 m²), severe hepatic disease, or acute conditions that predispose to hypoxia. It should also be used with caution in individuals with heart failure, alcohol dependence, or those undergoing radiographic contrast studies.