Product image of Metformax Sr 750 (Metformin Hydrochloride) supplied by GNH India

Metformax Sr 750

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformax Sr 750 (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformax Sr 750, is a biguanide presented as a 750 mg tablet for oral use. It treats type 2 diabetes mellitus by lowering blood glucose levels in adult patients.

GNH India supplies Metformax Sr 750 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Metformax Sr 750 (metformin) is used in the management of hyperglycemia associated with type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Prediabetes (impaired fasting glucose): helps delay progression to overt diabetes.
  • Polycystic ovary syndrome (PCOS): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin Hydrochloride primarily inhibits hepatic gluconeogenesis, reducing the amount of glucose released by the liver. It also enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal glucose absorption, collectively lowering circulating blood glucose levels.

Side Effects

Metformax Sr 750 may cause a range of adverse reactions. Most are mild and transient, but serious events can occur.

Common Side Effects

  • Gastrointestinal upset: nausea, vomiting, abdominal discomfort.
  • Diarrhea: loose stools, sometimes watery.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Loss of appetite: reduced desire to eat.
  • Weight loss: modest reduction in body weight.
  • Lactic acidosis (rare): symptoms include fatigue, muscle pain, rapid breathing.

Serious or Rare Side Effects

  • Severe hypoglycemia (when combined with other glucose‑lowering agents).
  • Hepatic dysfunction: elevated liver enzymes.
  • Allergic reactions: rash, pruritus, angioedema.
  • Vitamin B12 deficiency: neuropathy, anemia with long‑term use.

Precautions & Warnings

Metformax Sr 750 should be used with awareness of specific safety considerations.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic disease: avoid in patients with significant liver impairment.
  • Cardiovascular status: monitor for signs of lactic acidosis in heart failure.
  • Pregnancy and lactation: weigh potential benefits against risks; consult obstetric guidance.
  • Concomitant medications: review for drugs that may affect renal clearance or increase lactic acidosis risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metformax Sr 750 can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: risk of acute renal failure; discontinue metformin before and after imaging.
  • Cimetidine: may increase metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): heightened risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics (thiazides, loop): may affect renal function and glucose control.
  • ACE inhibitors/ARBs: monitor renal function and potassium levels.
  • Beta‑blockers: can mask hypoglycemia symptoms.
  • Alcohol: potentiates lactic acidosis risk.

Frequently Asked Questions

Metformax Sr 750 contains metformin hydrochloride and is indicated for the treatment of type 2 diabetes mellitus. It helps lower elevated blood glucose by improving insulin sensitivity and reducing hepatic glucose production.

Metformin Hydrochloride reduces the liver’s production of glucose, enhances peripheral uptake of glucose by muscle and fat cells, and modestly decreases intestinal absorption of glucose, resulting in lower blood sugar levels.

The specific dose of Metformax Sr 750 is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually.

Metformax Sr 750 should only be used in pregnancy or while breastfeeding if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should evaluate each case carefully.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Metformax Sr 750 belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, and SGLT2 inhibitors in its mechanism of reducing hepatic glucose output and improving insulin sensitivity. It is often used as first‑line therapy because of its efficacy, low risk of hypoglycemia, and cost‑effectiveness.

Store Metformax Sr 750 at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency.

Metformax Sr 750 is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water; it is not intended for crushing or chewing.

The most serious risk is lactic acidosis, a rare but potentially fatal condition characterized by rapid breathing, muscle pain, and abdominal discomfort. This risk is higher in patients with severe renal or hepatic impairment, heart failure, or excessive alcohol consumption.

Metformax Sr 750 is contraindicated in patients with known hypersensitivity to metformin, severe renal impairment (eGFR <30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those receiving iodinated contrast media without appropriate discontinuation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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