Metformin Accord

Active Ingredient:: Metformin Hydrochloride
Origin:: EU

Metformin Accord (Metformin Hydrochloride)

Q: What is Metformin Accord used for?

Metformin Accord is indicated for the management of type 2 diabetes mellitus in adult patients. It helps lower elevated blood glucose levels and assists in achieving target HbA1c values when used as part of a comprehensive diabetes care plan.

Q: How does Metformin Hydrochloride work?

Metformin Hydrochloride works by inhibiting hepatic gluconeogenesis, reducing the liver's production of glucose. It also enhances peripheral insulin sensitivity, promoting greater glucose uptake by muscle and adipose tissue, and modestly decreases intestinal glucose absorption.

Q: What is the usual dose of Metformin Accord?

The dose of Metformin Accord is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule for each patient.

Q: Is Metformin Accord safe during pregnancy or breastfeeding?

Metformin Accord is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy or lactation only if the potential benefits justify the potential risks, and under medical supervision.

Q: How do I order Metformin Accord from GNH India?

To order Metformin Accord, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Q: How does Metformin Accord compare with other antidiabetic agents?

Metformin Accord belongs to the biguanide class, differing from sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors. It does not stimulate insulin secretion, thus carries a lower risk of hypoglycaemia. It also offers weight‑neutral or modest weight‑loss effects, whereas some other agents may cause weight gain.

Q: How should Metformin Accord be stored and handled?

Metformin Accord should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, humidity and direct sunlight. Do not store in the bathroom or near heat sources.

Q: How is Metformin Accord administered?

Metformin Accord is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not crush or chew the tablets unless instructed otherwise.

Q: What are the most serious risks associated with Metformin Accord?

The most serious potential risk is lactic acidosis, a rare but life‑threatening condition that can occur in patients with severe renal or hepatic impairment. Other serious concerns include significant vitamin B12 deficiency, which may lead to neuropathy, and rare cases of hepatotoxicity.

Q: Who should not use Metformin Accord?

Metformin Accord is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those with severe hepatic disease or uncontrolled heart failure.

Metformin Hydrochloride, the active ingredient in Metformin Accord, is a Biguanide presented as a tablet for oral use. It reduces hepatic glucose production and enhances peripheral insulin sensitivity, providing glycaemic control for adults with type 2 diabetes mellitus.

GNH India supplies Metformin Accord as a licensed, GDP‑compliant international pharmaceutical supplier, delivering the product to hospitals, pharmacies and clinics worldwide through regulated manufacturing and quality‑assured distribution channels. All batches comply with EU pharmacopoeial specifications and are subject to rigorous stability testing.

Manufacturer / TM Owner

Accord Healthcare B.V.

Select Quantity

Pack/s

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

First Name

Last Name

Phone

Delivery Country

Delivery PostCode/Zipcode

Select Your Profile

I have read and agree to the terms & conditions, including the privacy policy, return policy, and usage terms as applicable to this request.

Indications & Clinical Uses

Metformin Accord, a biguanide antidiabetic, acts on glucose metabolism to improve glycaemic control.

Type 2 diabetes mellitus: lowers blood glucose levels and helps maintain target HbA1c values in adult patients.

How It Works

Metformin Hydrochloride primarily inhibits mitochondrial respiratory-chain complex I, leading to decreased hepatic gluconeogenesis. It also improves peripheral insulin sensitivity by enhancing glucose uptake in muscle and adipose tissue, and modestly reduces intestinal glucose absorption, collectively contributing to lower plasma glucose concentrations.

Side Effects

Metformin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

Gastrointestinal upset: nausea, abdominal discomfort, and diarrhea.
Metallic taste in the mouth.
Decreased appetite.

Serious or Rare Side Effects

Lactic acidosis: a rare but potentially fatal metabolic complication.
Severe vitamin B12 deficiency leading to neuropathy.
Hepatotoxicity: abnormal liver function tests in rare cases.

Precautions & Warnings

When prescribing Metformin Accord, clinicians should consider several safety measures.

Renal function assessment: evaluate eGFR before initiation and periodically.
Hepatic function monitoring: avoid use in patients with significant liver disease.
Contraindicated in severe renal impairment: do not use if eGFR <30 mL/min/1.73 m².
Alcohol consumption: limit intake to reduce risk of lactic acidosis.
Pregnancy and lactation: use only if benefits outweigh potential risks.
Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Metformin Accord can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

Iodinated contrast media: avoid concurrent use due to risk of acute renal failure.
Cimetidine: may increase metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

Diuretics (e.g., furosemide): may affect renal clearance of metformin.
Corticosteroids: can raise blood glucose, necessitating dose adjustment.
Beta‑blockers: may mask symptoms of hypoglycaemia.

Frequently Asked Questions

Metformin Accord is indicated for the management of type 2 diabetes mellitus in adult patients. It helps lower elevated blood glucose levels and assists in achieving target HbA1c values when used as part of a comprehensive diabetes care plan.

Metformin Hydrochloride works by inhibiting hepatic gluconeogenesis, reducing the liver's production of glucose. It also enhances peripheral insulin sensitivity, promoting greater glucose uptake by muscle and adipose tissue, and modestly decreases intestinal glucose absorption.

The dose of Metformin Accord is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule for each patient.

Metformin Accord is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy or lactation only if the potential benefits justify the potential risks, and under medical supervision.

To order Metformin Accord, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Metformin Accord belongs to the biguanide class, differing from sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors. It does not stimulate insulin secretion, thus carries a lower risk of hypoglycaemia. It also offers weight‑neutral or modest weight‑loss effects, whereas some other agents may cause weight gain.

Metformin Accord should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, humidity and direct sunlight. Do not store in the bathroom or near heat sources.

Metformin Accord is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not crush or chew the tablets unless instructed otherwise.

The most serious potential risk is lactic acidosis, a rare but life‑threatening condition that can occur in patients with severe renal or hepatic impairment. Other serious concerns include significant vitamin B12 deficiency, which may lead to neuropathy, and rare cases of hepatotoxicity.

Metformin Accord is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those with severe hepatic disease or uncontrolled heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 05 Sep 2026

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.