Product image of Metformin Aurobindo (Metformin Hydrochloride) supplied by GNH India

Metformin Aurobindo

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Aurobindo (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Aurobindo, is a biguanide presented as a unknown/unknown for oral use. It lowers elevated blood glucose levels in adults with type 2 diabetes mellitus by decreasing hepatic glucose production, reducing intestinal glucose absorption, and enhancing peripheral insulin sensitivity.

GNH India supplies Metformin Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines across global markets. The company adheres to stringent quality standards and regulatory requirements to ensure product integrity.

Manufacturer / TM Owner

Aurobindo Pharma România S.R.L.

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Indications & Clinical Uses

Metformin Aurobindo, a biguanide antidiabetic, is employed to manage hyperglycemia within the type 2 diabetes therapeutic pathway.

  • Type 2 diabetes mellitus: improves glycemic control in adults with type 2 diabetes.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes when used under medical supervision.
  • Polycystic ovary syndrome (PCOS): reduces insulin resistance and may improve menstrual regularity in women with PCOS.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting hepatic gluconeogenesis, thereby reducing endogenous glucose production. It also decreases glucose absorption from the gastrointestinal tract and enhances peripheral tissue sensitivity to insulin, facilitating greater glucose uptake. The drug does not stimulate insulin secretion, which contributes to its low risk of hypoglycemia when used as monotherapy.

Side Effects

Metformin Aurobindo may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or flatulence.
  • Diarrhea: loose, watery stools.
  • Metallic taste: transient metallic sensation.
  • Loss of appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal accumulation of lactate.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Vitamin B12 deficiency: long‑term use may lower B12 levels.

Precautions & Warnings

When prescribing Metformin Aurobindo, clinicians should observe several precautionary measures to minimize risk.

  • Renal function assessment: evaluate creatinine clearance before initiation and periodically thereafter.
  • Hepatic function monitoring: check liver enzymes, especially in patients with existing liver disease.
  • Lactic acidosis risk: avoid use in patients with conditions predisposing to hypoxia or severe infection.
  • Pregnancy and lactation: consider risks and benefits; use only if clearly needed.
  • Drug interaction vigilance: review concomitant medications that may increase metformin levels.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Metformin Aurobindo can interact with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: can raise metformin plasma concentrations.
  • Alcohol excess: potentiates lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics (thiazides): may impair renal function, enhancing metformin accumulation.
  • Beta‑blockers: can mask hypoglycemia symptoms when combined with insulin secretagogues.
  • NSAIDs: may reduce renal perfusion, affecting metformin clearance.
  • Sulfonylureas: increase risk of hypoglycemia when used together.

Frequently Asked Questions

Metformin Aurobindo contains metformin hydrochloride, a biguanide antidiabetic medication. It is primarily prescribed to lower elevated blood glucose in adults with type 2 diabetes mellitus, helping achieve target glycemic levels as part of a comprehensive diabetes management plan.

Metformin Hydrochloride reduces hepatic glucose production, limits intestinal glucose absorption, and improves peripheral insulin sensitivity. By acting on the liver, gut, and muscle cells, it lowers circulating glucose without directly stimulating insulin secretion, which contributes to a lower risk of hypoglycemia when used alone.

The exact dosage of Metformin Aurobindo is determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions without self‑adjusting the dose.

Safety of metformin during pregnancy or lactation should be evaluated by a qualified clinician. While some guidelines allow limited use when benefits outweigh risks, the decision is individualized. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and alternatives with their healthcare provider.

To request Metformin Aurobindo, visit the product page on gnhindia.com and submit an enquiry specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with sulfonylureas or insulin, metformin lowers glucose without stimulating insulin release, resulting in a lower intrinsic risk of hypoglycemia. It also promotes modest weight loss and has cardiovascular benefits in many patients. However, it may be less potent in rapidly reducing very high glucose levels, where combination therapy might be required.

Metformin Aurobindo should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the packaging.

Metformin Aurobindo is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a full glass of water and should not be crushed or chewed unless specifically instructed by a healthcare professional. Adherence to the prescribed schedule is essential for optimal glycemic control.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions causing hypoxia. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant vitamin B12 deficiency with long‑term use. Prompt medical attention is required if symptoms arise.

Metformin Aurobindo is contraindicated in individuals with known hypersensitivity to metformin, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in patients receiving iodinated contrast studies without adequate renal function assessment. Clinicians should also exercise caution in patients with liver disease or heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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