Product image of Metformin Bluefish (Metformin Hydrochloride) supplied by GNH India

Metformin Bluefish

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Bluefish (Metformin Hydrochloride)

Metformin, the active ingredient in Metformin Bluefish, is a Biguanide presented as an oral tablet for oral use. It is used to improve blood glucose control in adults with type 2 diabetes and can also be prescribed for polycystic ovary syndrome.

GNH India supplies Metformin Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Metformin is indicated for conditions affecting glucose metabolism and insulin sensitivity.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels.
  • Polycystic ovary syndrome: improves insulin resistance and may restore ovulatory function.
  • Prediabetes: reduces the risk of progression to type 2 diabetes by improving glycaemic control.

How It Works

  • Metformin acts primarily by inhibiting hepatic gluconeogenesis, thereby decreasing glucose output from the liver. It also reduces intestinal glucose absorption and enhances peripheral insulin sensitivity, facilitating greater glucose uptake into muscle and adipose tissue without directly stimulating insulin secretion.

Side Effects

Metformin is associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Metallic taste in the mouth.
  • Mild headache.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic disturbance.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Vitamin B12 deficiency with long‑term use.

Precautions & Warnings

Metformin should be used with careful clinical monitoring and patient education.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic disease: avoid in patients with significant liver impairment.
  • Cardiovascular status: use cautiously in patients with unstable heart failure.
  • Alcohol intake: limit consumption to reduce risk of lactic acidosis.
  • Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Metformin may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate acute renal failure, increasing lactic acidosis risk.
  • Cimetidine: may raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance renal effects; monitor kidney function.
  • Beta‑blockers: can mask hypoglycaemia symptoms.
  • Diuretics: may affect renal clearance of metformin.
  • Alcohol: potentiates lactic acidosis risk, especially with chronic use.

Frequently Asked Questions

Metformin Bluefish contains metformin hydrochloride and is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus and to address insulin resistance in polycystic ovary syndrome. It may also be used in prediabetes to delay progression to diabetes.

Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and enhances peripheral insulin sensitivity, allowing cells to take up glucose more efficiently without increasing insulin secretion.

The appropriate dose of Metformin Bluefish is determined by the prescribing clinician based on the individual’s medical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metformin during pregnancy or lactation is not fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin belongs to the biguanide class and is often first‑line therapy because it improves insulin sensitivity without causing weight gain. Compared with sulfonylureas, it has a lower risk of hypoglycaemia, and unlike insulin, it is taken orally.

Store Metformin Bluefish at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and discard any product that appears discoloured or damaged.

Metformin Bluefish is taken orally, usually with meals to minimise gastrointestinal upset. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute medical illness. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain or unusual fatigue develop.

Metformin Bluefish should be avoided in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving iodinated contrast studies without adequate hydration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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