Product image of Metformin Hexal (Metformin Hydrochloride) supplied by GNH India

Metformin Hexal

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Hexal (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Hexal, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adults by improving blood glucose control.
GNH India supplies Metformin Hexal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

  • Metformin Hexal, a biguanide antidiabetic, is used to manage hyperglycemia in type 2 diabetes and related insulin‑resistant conditions.
  • Type 2 diabetes mellitus: improves glycemic control by lowering fasting and post‑prandial glucose levels.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes.
  • Polycystic ovary syndrome (PCOS): reduces insulin resistance and may improve menstrual regularity.

How It Works

  • Metformin activates AMP‑activated protein kinase (AMPK) in liver and muscle cells, which suppresses hepatic gluconeogenesis, enhances peripheral glucose uptake, and improves insulin sensitivity, leading to reduced circulating glucose levels without directly stimulating insulin secretion.

Side Effects

Metformin Hexal may cause a range of adverse reactions. Monitoring and reporting are essential for patient safety.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal discomfort
  • Metallic taste
  • Loss of appetite
  • Flatulence

Serious or Rare Side Effects

  • Lactic acidosis
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Hypoglycemia when combined with other glucose‑lowering agents
  • Hepatic dysfunction
  • Pancreatitis
  • Anemia or hemolytic events

Precautions & Warnings

Before prescribing Metformin Hexal, clinicians should assess several safety factors.

  • Renal function: evaluate eGFR and avoid use in severe renal impairment.
  • Cardiovascular disease: monitor patients with heart failure for signs of lactic acidosis.
  • Lactic acidosis risk: avoid in conditions associated with hypoxia or severe infection.
  • Pregnancy and lactation: conduct a risk‑benefit assessment before use.
  • Drug interactions: review concomitant medications that may affect metformin levels.
  • Store at ambient temperature: keep below 25°C in the original container, protected from moisture.

Avoid Interactions

Metformin Hexal can interact with various medicines, requiring careful management.

Major Interactions (Avoid)

  • Iodinated contrast agents: increased risk of renal impairment and lactic acidosis.
  • Alcohol: potentiates lactic acidosis.
  • Cimetidine: may raise metformin plasma concentrations.
  • Rifampin: reduces metformin efficacy.
  • Nucleoside reverse transcriptase inhibitors: heightened lactic acidosis risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor renal function and electrolytes.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • ACE inhibitors/ARBs: watch for changes in kidney function.
  • NSAIDs: can affect renal clearance of metformin.
  • Thyroid hormones: may alter glucose metabolism.

Frequently Asked Questions

Metformin Hexal is a generic formulation of metformin hydrochloride indicated for the management of hyperglycemia in adults with type 2 diabetes mellitus. It is used as part of a comprehensive treatment plan that includes diet, exercise, and other glucose‑lowering therapies when needed.

Metformin lowers blood glucose primarily by activating AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis, reduces intestinal glucose absorption, and enhances peripheral insulin sensitivity, leading to improved uptake of glucose by muscle and fat tissues.

The dosage of Metformin Hexal is individualized. The prescribing healthcare professional determines the appropriate dose and titration schedule based on the patient’s glycemic targets, renal function, tolerability, and overall clinical condition.

Safety in pregnancy and lactation should be evaluated by the prescriber. Metformin crosses the placenta and is excreted in breast milk, so a risk‑benefit assessment is required before use in pregnant or nursing women.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and the necessary import documentation.

Compared with sulfonylureas, metformin does not cause insulin‑induced weight gain and carries a lower risk of hypoglycemia. It is often recommended as first‑line therapy and can be combined with other agents for additional glucose‑lowering effect.

Store Metformin Hexal at room temperature below 25 °C in the original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children.

Metformin Hexal is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water; they are not intended to be crushed or chewed.

The most serious adverse events include lactic acidosis, which may present with rapid breathing, muscle pain, abdominal discomfort, and unexplained fatigue, and severe hypersensitivity reactions such as Stevens‑Johnson syndrome. Immediate medical attention is required if these symptoms occur.

Metformin is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those undergoing radiographic contrast studies when renal function is at risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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