Product image of Metformin Hydrochloride Brown & Burk (Metformin Hydrochloride) supplied by GNH India

Metformin Hydrochloride Brown & Burk

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Hydrochloride Brown & Burk (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Hydrochloride Brown & Burk, is a biguanide presented as an oral tablet for oral use. It is employed to improve glycemic control in adults with type 2 diabetes mellitus by decreasing hepatic glucose production and increasing peripheral insulin sensitivity, thereby helping to lower elevated blood‑sugar levels.

GNH India supplies Metformin Hydrochloride Brown & Burk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide across multiple regulatory jurisdictions.

Manufacturer / TM Owner

Brown & Burk Uk Limited

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Indications & Clinical Uses

Metformin Hydrochloride is indicated for conditions within the type 2 diabetes mellitus therapeutic pathway.

  • Type 2 diabetes mellitus: improves glycemic control by lowering fasting plasma glucose and HbA1c levels.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting mitochondrial respiratory-chain complex I, which reduces hepatic gluconeogenesis. The resulting decrease in hepatic glucose output, together with enhanced peripheral glucose uptake and improved insulin receptor signaling, leads to lower circulating glucose concentrations without directly stimulating insulin secretion.

Side Effects

Metformin Hydrochloride may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: loose stools occurring especially during treatment initiation.
  • Metallic taste: transient alteration in taste perception.
  • Vitamin B12 deficiency: reduced absorption with long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated transaminases indicating liver injury.
  • Hypoglycemia: when combined with insulin or insulin secretagogues.

Precautions & Warnings

When prescribing Metformin Hydrochloride, clinicians should observe several precautionary measures to minimize risk.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic function: evaluate liver enzymes to rule out significant impairment.
  • Risk of lactic acidosis: avoid in patients with conditions predisposing to hypoxia or severe heart failure.
  • Concomitant medications: review for drugs that may increase metformin levels or lactic acidosis risk.
  • Elderly patients: start at lower doses and monitor tolerance closely.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformin Hydrochloride can interact with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol excess: heightens risk of lactic acidosis.
  • Carbamazepine: may reduce metformin efficacy.
  • Nifedipine: potential for increased metformin levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and potassium.
  • Sulfonylureas: increased risk of hypoglycemia when combined.
  • Warfarin: may require INR monitoring due to altered metabolism.

Frequently Asked Questions

Metformin Hydrochloride Brown & Burk is used to improve blood‑sugar control in adults with type 2 diabetes mellitus. It works by lowering hepatic glucose production and enhancing the body’s response to insulin, helping to achieve target glycemic levels as part of a comprehensive diabetes management plan.

Metformin Hydrochloride reduces the liver’s production of glucose and increases peripheral tissue sensitivity to insulin. By inhibiting mitochondrial complex I, it decreases gluconeogenesis, while also promoting glucose uptake in muscle and fat cells, resulting in lower circulating glucose without stimulating insulin secretion.

The appropriate dose of Metformin Hydrochloride is determined by the prescribing healthcare professional based on individual patient factors such as renal function, age, and glycemic response. The prescriber will select the strength and dosing schedule that best fits the patient’s therapeutic needs.

Safety of Metformin Hydrochloride in pregnancy or while breastfeeding has not been definitively established. Healthcare providers weigh potential benefits against possible risks, and the decision to use the medication during these periods should be made in consultation with a qualified medical professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin Hydrochloride belongs to the biguanide class and is often first‑line therapy for type 2 diabetes because it does not cause weight gain and has a low risk of hypoglycemia when used alone. Compared with sulfonylureas, it does not stimulate insulin release, and unlike insulin, it is administered orally.

Metformin Hydrochloride should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, excessive heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Metformin Hydrochloride is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water; they should not be crushed, chewed, or dissolved unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition characterized by the buildup of lactic acid in the blood. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant hepatic dysfunction, which require immediate medical attention.

Metformin Hydrochloride is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those receiving iodinated contrast studies without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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