Metformin Hydrochloride Genus Pharmaceuticals (Metformin)

Metformin acts primarily by activating AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis, reduces intestinal glucose absorption, and enhances peripheral insulin sensitivity. These combined effects lower circulating glucose without increasing insulin secretion.

The specific dose of Metformin Hydrochloride is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety of Metformin during pregnancy or lactation should be evaluated by a healthcare professional. While some guidelines allow its use in certain pregnant patients with diabetes, the decision depends on risk‑benefit assessment, and breastfeeding mothers should consult their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often preferred as first‑line therapy for type 2 diabetes because it improves insulin sensitivity without causing weight gain and has a low risk of hypoglycaemia when used alone. Compared with sulfonylureas or insulin, it does not stimulate insulin secretion and therefore carries fewer hypoglycaemic episodes.

Metformin Hydrochloride tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid environments.

Metformin Hydrochloride is taken orally, usually with meals to minimise gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute medical illness. Prompt medical attention is required if symptoms such as unexplained fatigue, muscle pain, or rapid breathing develop.

Metformin is contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and those receiving iodinated contrast studies without adequate renal function monitoring.