Metformin Hydrochloride Milpharm (Metformin Hydrochloride)

Metformin works by activating AMP‑activated protein kinase, which reduces hepatic glucose production, increases peripheral glucose uptake, and enhances insulin sensitivity. These actions lower circulating glucose without stimulating insulin release.

The exact dose of Metformin Hydrochloride is determined by the prescribing clinician based on the individual’s medical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety in pregnancy and lactation has not been fully established. Metformin should only be used during pregnancy or while breastfeeding if the prescriber judges that the potential benefits outweigh the possible risks to the mother and child.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is a first‑line biguanide that lowers glucose without causing hypoglycaemia when used alone, unlike sulfonylureas. It also offers benefits such as modest weight loss and a low risk of cardiovascular events, making it a preferred initial therapy for many patients with type 2 diabetes.

Metformin Hydrochloride tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Metformin Hydrochloride is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water; they should not be crushed, chewed, or dissolved unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute medical illnesses. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformin is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving iodinated contrast studies without adequate renal function monitoring.