Product image of Metformin Hydrochloride Stada (Metformin Hydrochloride) supplied by GNH India

Metformin Hydrochloride Stada

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Hydrochloride Stada (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Hydrochloride Stada, is a biguanide presented as a tablet for oral use. It reduces hepatic glucose production and improves peripheral insulin sensitivity, thereby lowering blood glucose levels in adults with type 2 diabetes mellitus.

GNH India supplies Metformin Hydrochloride Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured product availability for healthcare providers. The product complies with European Union pharmaceutical standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Genus Pharmaceuticals Limited

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Indications & Clinical Uses

Metformin Hydrochloride is indicated for conditions related to impaired glucose metabolism and is used primarily in the management of type 2 diabetes.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Prediabetes: delays progression to type 2 diabetes when combined with lifestyle modification.
  • Polycystic ovary syndrome: improves insulin resistance and may help regulate menstrual cycles (off‑label use).

How It Works

  • Metformin Hydrochloride acts by inhibiting mitochondrial respiratory‑chain complex I, which decreases hepatic gluconeogenesis. It also enhances peripheral glucose uptake by increasing insulin receptor tyrosine kinase activity and improves insulin sensitivity in muscle and adipose tissue. The net effect is reduced circulating glucose without stimulating insulin secretion. Additionally, metformin modestly reduces intestinal absorption of glucose and may alter gut microbiota, contributing to its antihyperglycemic profile.

Side Effects

Metformin Hydrochloride may cause a range of adverse reactions, most of which are related to the gastrointestinal system.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Diarrhea: loose stools, often transient.
  • Metallic taste: temporary alteration in taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal accumulation of lactate.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: marked elevation of liver enzymes.

Precautions & Warnings

When prescribing Metformin Hydrochloride, clinicians should consider several safety precautions to minimize risk.

  • Renal function: assess eGFR before initiation and periodically thereafter.
  • Hepatic function: avoid use in patients with significant liver disease.
  • Lactic acidosis risk: contraindicated in conditions associated with hypoxia or severe heart failure.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Alcohol consumption: limit intake as alcohol may increase lactic acidosis risk.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture.

Avoid Interactions

Metformin Hydrochloride can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may cause acute kidney injury, raising metformin levels.
  • Cimetidine: can increase metformin plasma concentration.
  • Alcohol: excessive intake raises risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Sulfonylureas: combined use can increase hypoglycemia risk.

Frequently Asked Questions

Metformin Hydrochloride Stada is an oral antidiabetic medication indicated for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues.

Metformin works primarily by inhibiting mitochondrial complex I, which reduces hepatic gluconeogenesis. It also enhances peripheral uptake of glucose by increasing insulin receptor activity, leading to lower circulating glucose without stimulating insulin secretion.

The dose of Metformin Hydrochloride Stada is individualized. A qualified prescriber determines the appropriate strength, frequency, and titration schedule based on the patient’s renal function, glycemic targets, and overall clinical condition.

Safety in pregnancy and lactation is not fully established. Use is generally reserved for situations where the potential benefit outweighs potential risks, and it should be prescribed only after careful evaluation by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Metformin belongs to the biguanide class and is often preferred as first‑line therapy because it does not cause hypoglycemia when used alone and may aid weight management. Compared with sulfonylureas, it has a lower risk of hypoglycemia but requires monitoring of renal function.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Metformin Hydrochloride Stada is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water; they are not intended for crushing, chewing, or dissolving unless specifically instructed by a healthcare professional.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions causing hypoxia. Prompt medical attention is required if symptoms such as unexplained fatigue, muscle pain, or rapid breathing develop.

Metformin is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those with conditions that predispose to hypoxia, such as uncontrolled heart failure or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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