Product image of Metformin Hydrochloride Syri Pharma (Metformin Hydrochloride) supplied by GNH India

Metformin Hydrochloride Syri Pharma

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Hydrochloride Syri Pharma (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Hydrochloride Syri Pharma, is a biguanide presented as an oral tablet for oral administration. It works by lowering hepatic glucose production, decreasing intestinal glucose absorption, and enhancing peripheral insulin sensitivity, thereby helping to achieve better glycaemic control in adults diagnosed with type 2 diabetes mellitus.

GNH India supplies Metformin Hydrochloride Syri Pharma as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets. The company adheres to stringent quality standards and regulatory requirements to ensure product integrity.

Manufacturer / TM Owner

Syri Pharma Limited

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Indications & Clinical Uses

Metformin Hydrochloride is an oral antihyperglycemic agent used primarily in the management of disorders related to insulin resistance and elevated blood glucose.

  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c levels.
  • Prediabetes (impaired glucose tolerance): helps delay or prevent progression to type 2 diabetes.
  • Polycystic ovary syndrome: reduces insulin resistance and may improve menstrual regularity.

How It Works

  • Metformin Hydrochloride exerts its antihyperglycaemic effect by inhibiting hepatic gluconeogenesis, decreasing intestinal absorption of glucose, and enhancing peripheral insulin‑mediated glucose uptake through activation of AMP‑activated protein kinase (AMPK) pathways, resulting in lower circulating glucose concentrations.

Side Effects

Metformin Hydrochloride may cause a range of adverse reactions, from mild gastrointestinal discomfort to rare but serious metabolic disturbances.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, often transient.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Vitamin B12 deficiency: reduced absorption over long‑term use.
  • Loss of appetite: decreased desire to eat.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic acidosis, a medical emergency.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: liver enzyme elevations or injury.
  • Pancreatitis: inflammation of the pancreas.
  • Hypoglycaemia (when combined with other glucose‑lowering agents): unusually low blood sugar.
  • Renal impairment worsening: decreased kidney function.

Precautions & Warnings

When prescribing Metformin Hydrochloride, clinicians should consider several safety aspects.

  • Renal function assessment: evaluate creatinine clearance before initiation and periodically thereafter.
  • Hepatic disease monitoring: avoid use in patients with significant liver dysfunction.
  • Cardiovascular status: use cautiously in patients with unstable heart failure.
  • Alcohol consumption: advise limiting intake to reduce lactic acidosis risk.
  • Vitamin B12 monitoring: check levels during long‑term therapy.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Metformin Hydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure, increasing lactic acidosis risk.
  • Cimetidine: can raise metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): may increase toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and potassium.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Thyroid hormones: may require dose adjustments.

Frequently Asked Questions

Metformin Hydrochloride Syri Pharma is an oral antihyperglycaemic medication indicated for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose levels by improving insulin sensitivity and reducing hepatic glucose production.

Metformin works primarily by activating AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis, reduces intestinal glucose absorption, and enhances peripheral uptake of glucose into muscle cells, collectively lowering blood sugar concentrations.

The appropriate dose of Metformin Hydrochloride is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Metformin during pregnancy are limited, and its use should be considered only if the potential benefit outweighs any risk. Metformin is excreted in breast milk; therefore, breastfeeding mothers should discuss continuation with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is a first‑line biguanide distinguished by its low risk of hypoglycaemia, weight neutrality or modest loss, and cardiovascular benefit profile. Compared with sulfonylureas, it does not stimulate insulin secretion, and unlike newer agents such as SGLT2 inhibitors, it does not cause urinary glucose loss.

Metformin Hydrochloride tablets should be stored at ambient temperature, below 25 °C, in the original container, protected from moisture, heat and direct sunlight. Keep the product out of reach of children.

Metformin Hydrochloride is taken orally, usually with meals to minimise gastrointestinal upset. Tablets should be swallowed whole with a full glass of water; they are not intended for crushing, chewing, or sublingual administration.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, hypoxia, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain or unusual fatigue develop.

Metformin is contraindicated in patients with known hypersensitivity to the drug, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those receiving iodinated contrast studies without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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