Product image of Metformin Hydrochloride Teva (Metformin) supplied by GNH India

Metformin Hydrochloride Teva

Active Ingredient:
Metformin
Origin:
EU

Metformin Hydrochloride Teva (Metformin)

Metformin, the active ingredient in Metformin Hydrochloride Teva, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus by improving blood‑glucose control in adult patients.
GNH India supplies Metformin Hydrochloride Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharmaceuticals Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Metformin is an oral antidiabetic that lowers elevated blood glucose levels in several related conditions.
  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes.
  • Polycystic ovary syndrome: reduces insulin resistance and may improve menstrual regularity.

How It Works

  • Metformin acts primarily by inhibiting hepatic gluconeogenesis, thereby decreasing glucose production. It also reduces intestinal glucose absorption and enhances peripheral insulin sensitivity, facilitating greater glucose uptake by muscle and adipose tissue. These combined actions lower fasting and post‑prandial blood glucose without stimulating insulin secretion.

Side Effects

Metformin is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Abdominal discomfort
  • Metallic taste
  • Loss of appetite
  • Flatulence

Serious or Rare Side Effects

  • Lactic acidosis (potentially fatal)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hepatic dysfunction
  • Vitamin B12 deficiency with long‑term use
  • Hypoglycaemia when combined with other glucose‑lowering agents

Precautions & Warnings

Metformin requires careful monitoring and patient education before and during therapy.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic function: evaluate liver enzymes as impaired function increases lactic acidosis risk.
  • Risk of lactic acidosis: avoid in patients with conditions predisposing to hypoxia.
  • Concomitant medications: review drugs that may affect renal clearance or increase acidosis risk.
  • Elderly patients: consider dose reduction and close monitoring.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformin may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis.
  • Cimetidine: may increase metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): raise risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Sulfonylureas: increase risk of hypoglycaemia.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • NSAIDs: may impair renal clearance of metformin.

Frequently Asked Questions

Metformin Hydrochloride Teva is an oral biguanide indicated for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose by improving insulin sensitivity and reducing hepatic glucose production, thereby supporting better glycaemic control in adult patients.

Metformin reduces the liver’s production of glucose, decreases the absorption of glucose from the intestine, and enhances the responsiveness of muscle and fat cells to insulin. These actions collectively lower fasting and post‑prandial blood glucose levels without directly stimulating insulin secretion.

The appropriate dose of Metformin Hydrochloride Teva is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metformin in pregnancy and lactation has not been definitively established. Healthcare providers may weigh potential benefits against possible risks on a case‑by‑case basis. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often preferred as first‑line therapy because it does not cause weight gain and has a low risk of hypoglycaemia when used alone. Compared with sulfonylureas, it works by improving insulin sensitivity rather than stimulating insulin release, and it has a well‑documented cardiovascular safety profile.

Metformin Hydrochloride Teva should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions causing hypoxia. Prompt medical attention is required if symptoms such as unexplained fatigue, rapid breathing, or abdominal pain develop.

Metformin is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those who have received iodinated contrast media within the previous 48 hours. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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