Product image of Metformin Relonchem (Metformin Hydrochloride) supplied by GNH India

Metformin Relonchem

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Relonchem (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Relonchem, is a biguanide presented as an oral tablet for oral use. It is used to improve blood glucose control in adults with type 2 diabetes mellitus and related metabolic conditions.

GNH India supplies Metformin Relonchem as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Relon Chem Limited

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Indications & Clinical Uses

Metformin Relonchem belongs to the biguanide class and is indicated for disorders of glucose metabolism.

  • Type 2 diabetes mellitus: helps lower fasting and post‑prandial blood glucose levels in adults.
  • Prediabetes (impaired glucose tolerance): reduces progression to overt diabetes when combined with lifestyle measures.
  • Polycystic ovary syndrome: improves insulin resistance and may aid menstrual regularity in women.

How It Works

  • Metformin Hydrochloride reduces hepatic gluconeogenesis, decreases intestinal absorption of glucose, and enhances peripheral insulin sensitivity, leading to increased uptake of glucose by muscle and adipose tissue. These actions collectively lower circulating blood glucose without directly stimulating insulin secretion.

Side Effects

Metformin Relonchem may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Loss of appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: abnormal liver function tests.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Before initiating Metformin Relonchem, several safety considerations should be reviewed.

  • Renal function assessment: evaluate kidney function and avoid use in severe renal impairment.
  • Hepatic status monitoring: assess liver disease as it may increase lactic acidosis risk.
  • Cardiovascular disease: use cautiously in patients with unstable heart failure.
  • Alcohol consumption: limit intake to reduce lactic acidosis potential.
  • Concomitant medications: review for drugs that affect renal clearance.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformin Relonchem can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate lactic acidosis; discontinue metformin before and after imaging.
  • Alcohol: excessive intake increases risk of lactic acidosis.
  • Cimetidine: can raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • Digoxin: may require dose adjustment due to altered renal clearance.

Frequently Asked Questions

Metformin Relonchem contains metformin hydrochloride, a biguanide oral antidiabetic that is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus and, in some cases, to manage prediabetes or insulin resistance associated with polycystic ovary syndrome.

Metformin lowers blood glucose by inhibiting hepatic glucose production, reducing intestinal glucose absorption, and enhancing peripheral insulin sensitivity, which together increase the uptake of glucose by muscle and fat cells without stimulating insulin secretion.

The dosage of Metformin Relonchem is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of metformin during pregnancy or lactation depends on clinical judgment. It may be used when the potential benefit outweighs risks, but the prescriber should evaluate each case. Breastfeeding mothers should discuss potential exposure with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often first‑line therapy because it improves insulin sensitivity without causing weight gain and has a well‑established safety profile. Compared with sulfonylureas, it has a lower risk of hypoglycemia, and unlike some newer agents, it is generally less expensive and widely available.

Metformin Relonchem should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Metformin Relonchem is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, liver disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformin Relonchem is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those receiving iodinated contrast media without appropriate discontinuation. The prescriber should assess each individual’s suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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