Product image of Metformin Teva (Metformin Hydrochloride) supplied by GNH India

Metformin Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Teva, is a biguanide presented as an oral tablet for oral use. It reduces hepatic glucose production and improves peripheral insulin sensitivity, thereby lowering elevated blood glucose levels in adults diagnosed with type 2 diabetes mellitus.

GNH India supplies Metformin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to essential antidiabetic therapy.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Metformin Teva is a biguanide indicated for conditions related to impaired glucose regulation.
  • Type 2 diabetes mellitus: improves glycemic control by lowering fasting and post‑prandial blood glucose levels.
  • Insulin resistance: enhances peripheral insulin sensitivity, aiding glucose uptake.
  • Hyperglycemia: reduces hepatic glucose output, contributing to overall blood sugar reduction.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting mitochondrial respiratory-chain complex I, which decreases hepatic gluconeogenesis and increases peripheral glucose uptake. It also activates AMP‑activated protein kinase (AMPK), leading to improved insulin sensitivity and reduced intestinal glucose absorption, collectively contributing to lower plasma glucose concentrations.

Side Effects

Metformin Teva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, especially during treatment initiation.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: transient alteration in taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Metformin Teva requires careful patient assessment and monitoring to minimize risks.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic function: evaluate liver enzymes, especially in patients with existing liver disease.
  • Risk of lactic acidosis: avoid in patients with hypoxia, heart failure, or severe infection.
  • Concomitant medications: review for drugs that may impair renal function or increase metformin levels.
  • Patient education: advise on recognizing gastrointestinal symptoms and when to seek medical attention.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformin Teva can interact with several medicines, necessitating vigilance.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • NSAIDs: may impair renal function, increasing metformin exposure.

Frequently Asked Questions

Metformin Teva is a generic formulation of metformin hydrochloride indicated for the management of type 2 diabetes mellitus in adult patients. It helps lower elevated blood glucose by decreasing hepatic glucose production and improving the body's response to insulin.

Metformin Hydrochloride primarily inhibits mitochondrial complex I, which reduces gluconeogenesis in the liver. It also activates AMP‑activated protein kinase, enhancing peripheral insulin sensitivity and decreasing intestinal glucose absorption, resulting in lower circulating glucose levels.

The appropriate dose of Metformin Teva is determined by the prescribing healthcare professional based on individual patient factors such as renal function, glycemic targets, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Metformin may be used during pregnancy only if clearly needed and prescribed by a qualified clinician, as safety data are limited. It is excreted in breast milk, so a risk‑benefit assessment should be performed before breastfeeding while on metformin.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin belongs to the biguanide class and is often first‑line therapy for type 2 diabetes because of its efficacy, low risk of hypoglycemia and favorable impact on weight. Compared with sulfonylureas or insulin, metformin does not cause weight gain and has a well‑established safety profile when used appropriately.

Metformin Teva tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Metformin Teva is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically directed by a healthcare professional.

The most serious adverse effect is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions causing hypoxia. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformin Teva is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those with known hypersensitivity to metformin or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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