Product image of Metformin Teva (Metformin Hydrochloride) supplied by GNH India

Metformin Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin Teva, is a biguanide presented as an oral dosage form for oral use. It is used to improve blood glucose control in adults with type 2 diabetes mellitus. The drug works by decreasing hepatic glucose production and enhancing peripheral insulin sensitivity, helping to lower elevated blood sugar levels.

GNH India supplies Metformin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution to meet the needs of healthcare providers.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Metformin Teva is a biguanide that acts on glucose metabolism in type 2 diabetes and related conditions.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Impaired glucose tolerance: delays progression to overt diabetes.
  • Polycystic ovary syndrome: improves insulin resistance and may restore ovulatory function.

How It Works

  • Metformin Hydrochloride primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK). This reduces liver glucose output and increases peripheral glucose uptake in muscle and adipose tissue. The drug also improves insulin receptor signaling and decreases intestinal absorption of glucose, collectively contributing to lower plasma glucose concentrations without stimulating insulin secretion.

Side Effects

Metformin Teva may cause a range of adverse reactions, most of which are related to the gastrointestinal tract.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: altered taste sensation.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: decreased absorption over long term.

Serious or Rare Side Effects

  • Lactic acidosis: accumulation of lactate leading to metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Hypoglycemia: especially when combined with insulin or sulfonylureas.

Precautions & Warnings

When prescribing Metformin Teva, clinicians should consider several safety precautions to minimize risk.

  • Renal function: assess baseline creatinine clearance and monitor periodically.
  • Lactic acidosis risk: avoid in patients with severe renal or hepatic impairment.
  • Alcohol consumption: limit intake to reduce lactic acidosis potential.
  • Pregnancy: evaluate benefits versus risks and consult obstetric guidance.
  • Drug interactions: review concomitant medications that may affect metformin levels.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Metformin Teva can interact with other medicines, altering its plasma concentration or increasing adverse effect risk.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: can raise metformin plasma levels, heightening toxicity.
  • Alcohol excess: synergistic effect on lactate accumulation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • Other antidiabetic agents: combined therapy may increase hypoglycemia risk.

Frequently Asked Questions

Metformin Teva is indicated for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose levels by improving the body’s response to insulin and reducing the amount of glucose produced by the liver.

Metformin Hydrochloride activates AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis and increases peripheral glucose uptake. These actions lower circulating glucose without stimulating insulin secretion, making it effective for patients with insulin resistance.

The appropriate dose of Metformin Teva is individualized by the prescribing clinician based on factors such as the patient’s renal function, glycemic targets, and tolerance. Dosage adjustments are made according to clinical response and safety considerations.

Safety of Metformin Teva in pregnancy or while breastfeeding should be evaluated by a healthcare professional. The drug may be used when the potential benefit outweighs any potential risk, and decisions are made on a case‑by‑case basis.

To order Metformin Teva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin Teva belongs to the biguanide class and is often used as first‑line therapy because it does not cause weight gain and has a low risk of hypoglycemia when used alone. Compared with sulfonylureas or insulin, it works without stimulating insulin release, making it suitable for patients with insulin resistance.

Metformin Teva should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metformin Teva is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant hepatic dysfunction.

Metformin Teva is contraindicated in patients with known severe renal impairment, acute or chronic metabolic acidosis, and those with a history of lactic acidosis. It should also be avoided in individuals with hypersensitivity to metformin or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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