Metformin Teva B.V. (Metformin Hydrochloride)

Metformin works by inhibiting mitochondrial complex I, which reduces the liver’s production of glucose. This energy shift activates AMP‑activated protein kinase (AMPK), a cellular sensor that enhances glucose uptake in muscle and fat tissue while suppressing fat synthesis. The combined effect lowers circulating glucose without stimulating insulin release.

The appropriate Metformin dose is individualized by the prescribing healthcare professional based on factors such as the patient’s renal function, glycemic targets, concomitant medications, and tolerance. Dosage may be started low and gradually increased to balance efficacy with the risk of gastrointestinal side effects.

Metformin is classified as pregnancy category unknown in many regions, and its safety profile in pregnancy is not fully established. It may be used during pregnancy only when the potential benefit outweighs the risk, and under specialist supervision. Metformin is excreted in breast milk; breastfeeding mothers should discuss risks and alternatives with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Metformin belongs to the biguanide class and differs from sulfonylureas, which stimulate insulin secretion, and from insulin itself, which replaces the hormone. Metformin does not cause hypoglycemia when used alone, has a favorable effect on weight, and may improve cardiovascular outcomes, making it a first‑line therapy in most guidelines.

Metformin tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Metformin is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets are swallowed whole with a full glass of water. The specific dosing schedule—once, twice, or thrice daily—is determined by the prescriber based on the individual’s therapeutic needs.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions that cause tissue hypoxia. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant vitamin B12 deficiency with prolonged use.

Metformin is contraindicated in patients with known hypersensitivity to the drug, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, and in those with conditions that predispose to hypoxia such as severe heart failure or recent myocardial infarction. Clinicians should also exercise caution in the elderly and in patients with liver disease.