Product image of Metformin Teva Uk (Metformin Hydrochloride) supplied by GNH India

Metformin Teva Uk

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Teva Uk (Metformin Hydrochloride)

Metformin, the active ingredient in Metformin Teva Uk, is a biguanide presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adult patients, helping to lower elevated blood glucose levels by improving insulin sensitivity and reducing hepatic glucose production.

GNH India supplies Metformin Teva Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets and ensuring consistent quality across batches.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

Metformin is a biguanide antidiabetic agent used to improve glycaemic control in several glucose‑related conditions.

  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c levels.
  • Prediabetes (impaired fasting glucose): delays progression to overt diabetes when used with lifestyle measures.
  • Polycystic ovary syndrome: assists in restoring ovulatory cycles and reducing insulin resistance.

How It Works

  • Metformin primarily inhibits mitochondrial respiratory‑chain complex I, leading to reduced hepatic gluconeogenesis. The resulting decrease in hepatic glucose output, together with enhanced peripheral glucose uptake in muscle and adipose tissue, improves insulin sensitivity. It also modestly lowers intestinal glucose absorption and may influence gut microbiota, contributing to its overall antihyperglycaemic effect.

Side Effects

Metformin is associated with a range of adverse reactions, most of which are related to the gastrointestinal tract, while rare events can be serious.

Common Side Effects

  • Nausea: mild stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: transient alteration of taste.

Serious or Rare Side Effects

  • Lactic acidosis: life‑threatening accumulation of lactate.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Vitamin B12 deficiency: decreased absorption with long‑term therapy.

Precautions & Warnings

When prescribing Metformin, clinicians should evaluate several safety considerations to minimise risk.

  • Renal function: assess eGFR before initiation and periodically thereafter.
  • Hepatic disease: use with caution in patients with liver impairment.
  • Alcohol intake: advise avoidance of excessive alcohol to reduce lactic acidosis risk.
  • Concomitant hypoglycaemic agents: monitor for additive glucose‑lowering effects.
  • Pregnancy and lactation: discuss potential risks and benefits with the prescriber.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Metformin may interact with other medicines, altering its plasma concentration or increasing the risk of adverse events.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis.
  • Cimetidine: may raise metformin plasma levels, increasing toxicity risk.
  • Alcohol: excessive intake heightens lactic acidosis potential.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycaemia.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors or ARBs: require renal function monitoring when combined.

Frequently Asked Questions

Metformin Teva Uk is a generic biguanide tablet indicated for the treatment of type 2 diabetes mellitus. It helps lower elevated blood glucose by improving the body’s response to insulin and decreasing the amount of glucose produced by the liver.

Metformin works by inhibiting hepatic gluconeogenesis, which reduces the liver’s production of glucose. It also enhances peripheral insulin sensitivity, allowing muscle and fat cells to take up glucose more efficiently, and modestly reduces intestinal glucose absorption.

The appropriate dose of Metformin Teva Uk is determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Metformin may be used during pregnancy or lactation only when clearly needed and after a risk‑benefit assessment by the prescriber. It crosses the placenta and is excreted in breast milk, so clinicians should discuss potential advantages and risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Metformin Teva Uk. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas or insulin, Metformin does not cause weight gain and has a low risk of hypoglycaemia when used alone. It is often preferred as first‑line therapy for type 2 diabetes because of its efficacy, safety profile, and cardiovascular benefits observed in large clinical studies.

Metformin Teva Uk tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.

Metformin Teva Uk is taken orally, usually with meals to minimise gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not crush or chew the tablets unless instructed otherwise.

The most serious risk is lactic acidosis, a rare but potentially fatal condition characterized by rapid breathing, muscle pain and abdominal discomfort. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome and significant vitamin B12 deficiency with long‑term use.

Metformin is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and those receiving iodinated contrast studies without adequate renal monitoring. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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