Product image of Metformin Xr Teva (Metformin Hydrochloride) supplied by GNH India

Metformin Xr Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformin Xr Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformin XR, is a biguanide presented as an extended-release tablet for oral use. It treats type 2 diabetes mellitus in adult patients.
GNH India supplies Metformin XR as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

1
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Indications & Clinical Uses

Metformin XR is an oral antidiabetic agent indicated for the management of glucose control in type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycaemic control by lowering fasting and post‑prandial blood glucose levels.

How It Works

  • Metformin Hydrochloride reduces hepatic gluconeogenesis, decreases intestinal glucose absorption, and enhances peripheral insulin sensitivity. By activating AMP‑activated protein kinase (AMPK), it modulates key metabolic pathways that lower circulating glucose without stimulating insulin secretion.

Side Effects

Metformin XR may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration in taste perception.
  • Headache: mild tension‑type headache.
  • Decreased appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic acidosis.
  • Severe hypoglycaemia: usually when combined with insulin or sulfonylureas.
  • Hepatic failure: rare liver dysfunction.
  • Allergic reactions: rash, pruritus, or angio‑edema.
  • Vitamin B12 deficiency: long‑term use may lower B12 levels.
  • Myopathy: muscle pain or weakness in rare cases.

Precautions & Warnings

Metformin XR requires careful patient assessment and monitoring to minimise risks.

  • Renal function monitoring: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic function assessment: evaluate liver enzymes in patients with known liver disease.
  • Risk of lactic acidosis: avoid in patients with hypoxia, severe heart failure, or uncontrolled infection.
  • Dose adjustment in elderly: start low and titrate slowly.
  • Concomitant medication review: consider interactions that may affect renal clearance.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformin XR can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: can raise metformin plasma concentrations.
  • Alcohol excess: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Diuretics (loop or thiazide): can affect renal clearance of metformin.
  • ACE inhibitors/ARBs: monitor renal function and electrolytes.
  • NSAIDs: may impair renal function, increasing metformin exposure.
  • Corticosteroids: can raise blood glucose, requiring dose adjustments.

Frequently Asked Questions

Metformin XR is an extended‑release oral formulation of metformin hydrochloride indicated for the treatment of type 2 diabetes mellitus. It helps lower elevated blood glucose levels by improving the body’s response to insulin and reducing glucose production in the liver.

Metformin Hydrochloride activates AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis, reduces intestinal glucose absorption, and enhances peripheral insulin sensitivity. These actions collectively lower fasting and post‑prandial blood glucose without directly stimulating insulin secretion.

The dosage of Metformin XR is individualized by the prescribing healthcare professional based on the patient’s glycaemic targets, renal function, and tolerability. The prescriber determines the appropriate starting dose and any subsequent titration.

Safety of Metformin XR in pregnancy has not been definitively established; it is generally used only when the potential benefit justifies the potential risk. Metformin is excreted in breast milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformin XR provides a once‑daily dosing schedule with a smoother plasma concentration profile, which can improve gastrointestinal tolerability compared with immediate‑release formulations that require multiple daily doses. Both contain the same active ingredient and share similar efficacy in glucose control.

Store Metformin XR at ambient temperature, below 25 °C, in the original blister pack or container. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain product stability throughout its shelf life.

Metformin XR tablets are taken orally, usually with the evening meal to reduce gastrointestinal upset. The tablet should be swallowed whole with a full glass of water; it must not be split, crushed, or chewed.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or conditions causing hypoxia. Prompt medical attention is required if symptoms such as unexplained fatigue, rapid breathing, or abdominal pain develop.

Metformin XR is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and those receiving iodinated contrast media for imaging studies unless renal function is re‑evaluated afterward.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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