Metformin-Xr Teva (Metformin Hydrochloride)

Metformin hydrochloride primarily inhibits hepatic gluconeogenesis, lowering the amount of glucose released by the liver. It also activates AMP‑activated protein kinase (AMPK) in muscle and fat cells, which enhances insulin‑mediated glucose uptake and improves overall insulin sensitivity.

The dose of Metformin‑Xr Teva is individualized by the prescribing clinician based on the patient’s glycaemic targets, renal function, and tolerability. The prescriber determines the appropriate strength, frequency, and titration schedule.

Safety of metformin during pregnancy or lactation depends on clinical judgment. It is sometimes continued in pregnant women with diabetes when benefits outweigh risks, but the decision should be made by the treating physician. Metformin is excreted in breast milk, so a risk‑benefit assessment is required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is the first‑line oral therapy for type 2 diabetes and differs from sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors by primarily reducing hepatic glucose output and improving insulin sensitivity without causing weight gain. It has a well‑established safety profile and is often combined with other agents when additional glucose lowering is needed.

Metformin‑Xr Teva tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Metformin‑Xr Teva is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

The most serious adverse event is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute medical illnesses. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformin‑Xr Teva is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving iodinated contrast studies without adequate renal monitoring.