Product image of Metformina Aurobindo (Metformin Hydrochloride) supplied by GNH India

Metformina Aurobindo

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Aurobindo (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Aurobindo, is a biguanide presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults by improving blood‑glucose control.

GNH India supplies Metformina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Metformina Aurobindo is a biguanide indicated for disorders of glucose metabolism.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels.
  • Prediabetes (impaired glucose tolerance): reduces the risk of progression to type 2 diabetes.
  • Polycystic ovary syndrome (off‑label): helps improve insulin sensitivity and may restore ovulatory cycles.

How It Works

  • Metformin Hydrochloride primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK). This reduces liver glucose output and increases peripheral glucose uptake in muscle and adipose tissue, enhancing insulin sensitivity without stimulating insulin secretion.

Side Effects

Metformina Aurobindo may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: watery stools, often transient.
  • Metallic taste: altered taste perception.
  • Flatulence: increased intestinal gas.
  • Weight loss: modest reduction in body weight.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes.
  • Vitamin B12 deficiency: may develop with long‑term therapy.
  • Hypoglycemia: usually when combined with other glucose‑lowering agents.

Precautions & Warnings

Patients should be monitored for conditions that increase the risk of adverse events.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic function: evaluate liver enzymes, especially in patients with existing liver disease.
  • Lactic acidosis risk: avoid in patients with severe heart, respiratory, or circulatory failure.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Drug interactions: review concomitant medications that may affect metformin clearance.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Metformina Aurobindo can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Alcohol: may precipitate lactic acidosis.
  • Iodinated contrast agents: can cause acute renal impairment, increasing metformin accumulation.
  • Cimetidine: may raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemic symptoms.
  • Diuretics (especially thiazides): can affect renal clearance.
  • ACE inhibitors or ARBs: may alter renal function.
  • NSAIDs: increase risk of renal dysfunction.
  • Calcium channel blockers: may modestly raise metformin levels.

Frequently Asked Questions

Metformina Aurobindo contains metformin hydrochloride, a biguanide that is prescribed to improve blood‑glucose control in adults with type 2 diabetes mellitus and to reduce the risk of progression from prediabetes to diabetes.

Metformin activates AMP‑activated protein kinase (AMPK), which suppresses hepatic glucose production and enhances peripheral insulin sensitivity, leading to lower circulating glucose without increasing insulin secretion.

The dose of Metformina Aurobindo is individualized by the prescribing clinician based on the patient’s glycaemic targets, renal function, and tolerability. The prescriber determines the appropriate strength and dosing schedule.

Safety in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformina Aurobindo belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, and SGLT2 inhibitors. It lowers glucose without stimulating insulin release, carries a low risk of hypoglycaemia when used alone, and may aid weight management, whereas other classes have distinct mechanisms and side‑effect profiles.

Metformina Aurobindo should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed.

The medication is taken orally, usually with meals to minimise gastrointestinal discomfort. Tablets are swallowed whole with a glass of water; they should not be crushed, chewed, or split unless the prescriber specifically advises otherwise.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, heart failure, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformina Aurobindo is contraindicated in individuals with known hypersensitivity to metformin, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, and those receiving radiographic contrast studies that may affect kidney function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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