Product image of Metformina Aurobindo Italia (Metformin Hydrochloride) supplied by GNH India

Metformina Aurobindo Italia

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Aurobindo Italia (Metformin Hydrochloride)

Metformin, the active ingredient in Metformina Aurobindo Italia, is a biguanide presented as an oral tablet for oral use. It is used to improve glycemic control in adults with type 2 diabetes mellitus.
GNH India supplies Metformina Aurobindo Italia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Metformina Aurobindo Italia belongs to the biguanide class and is indicated for conditions related to impaired glucose regulation.
  • Type 2 diabetes mellitus: improves blood glucose control and reduces HbA1c levels.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes.
  • Polycystic ovary syndrome (PCOS): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin reduces hepatic gluconeogenesis, decreases intestinal glucose absorption, and enhances peripheral insulin sensitivity by activating AMP‑activated protein kinase (AMPK), leading to lower circulating glucose levels without stimulating insulin secretion.

Side Effects

Metformina Aurobindo Italia may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: frequent loose stools, especially during treatment initiation.
  • Metallic taste: transient alteration in taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic complication.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.
  • Hypoglycemia: usually when combined with other glucose‑lowering agents.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

  • Before prescribing Metformina Aurobindo Italia, clinicians should consider several safety factors.
  • Renal function: assess creatinine clearance and avoid use in severe renal impairment.
  • Liver disease: evaluate hepatic status as dysfunction may increase risk of lactic acidosis.
  • Cardiac failure: monitor patients with congestive heart failure for signs of hypoxia.
  • Elderly patients: start at lower doses and titrate cautiously.
  • Alcohol consumption: advise limiting intake to reduce lactic acidosis risk.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformina Aurobindo Italia can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol excess: raises risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • NSAIDs: may impair renal function, increasing metformin exposure.
  • Corticosteroids: can raise blood glucose, requiring dose adjustments.

Frequently Asked Questions

Metformina Aurobindo Italia contains metformin, a biguanide antidiabetic agent indicated primarily for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose by improving insulin sensitivity and reducing hepatic glucose production.

Metformin activates AMP‑activated protein kinase (AMPK) in liver and muscle cells, which suppresses gluconeogenesis, decreases intestinal glucose absorption, and enhances peripheral uptake of glucose. These actions lower fasting and post‑prandial blood sugar without increasing insulin secretion.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s renal function, glycemic targets, and tolerability. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Metformin crosses the placenta and is excreted in breast milk. Its safety in pregnancy and lactation should be evaluated by the treating physician, weighing potential benefits against possible risks to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often preferred as first‑line therapy because it improves insulin sensitivity without causing weight gain and has a low risk of hypoglycemia compared with sulfonylureas or insulin. Unlike newer agents such as SGLT2 inhibitors, it does not increase urinary glucose excretion.

Store the tablets at room temperature, preferably below 25 °C, in the original packaging to protect them from moisture and direct sunlight. Keep out of reach of children.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most critical adverse event is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformina Aurobindo Italia is contraindicated in individuals with known hypersensitivity to metformin, severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, and in patients receiving radiographic contrast studies without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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