Product image of Metformina Azevedos (Metformin Hydrochloride) supplied by GNH India

Metformina Azevedos

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Azevedos (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Azevedos, is a biguanide presented as an oral dosage form for oral use. It is used to lower elevated blood glucose levels in adults with type 2 diabetes mellitus and related insulin‑resistant conditions.

GNH India supplies Metformina Azevedos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Azevedos - Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metformina Azevedos, a biguanide antidiabetic, is employed in metabolic disorders that involve insulin resistance.

  • Type 2 diabetes mellitus: improves glycaemic control by reducing hepatic glucose output and enhancing peripheral insulin sensitivity.
  • Impaired glucose tolerance (prediabetes): helps delay progression to overt diabetes through improved insulin action.
  • Polycystic ovary syndrome: assists in normalising metabolic parameters and reducing hyperinsulinaemia.

How It Works

  • Metformin Hydrochloride primarily inhibits mitochondrial respiratory‑chain complex I, decreasing hepatic gluconeogenesis. It also activates AMP‑activated protein kinase (AMPK), which enhances peripheral glucose uptake and fatty‑acid oxidation, thereby lowering circulating glucose levels without stimulating insulin secretion.

Side Effects

Metformina Azevedos may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhoea: frequent loose stools, especially at treatment initiation.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Loss of appetite: reduced desire to eat.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hypoglycaemia: when combined with other glucose‑lowering agents.
  • Hepatic dysfunction: rare liver enzyme elevations.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Renal impairment: worsening kidney function in susceptible patients.

Precautions & Warnings

Metformina Azevedos requires careful patient assessment and monitoring.

  • Renal function assessment: evaluate eGFR before initiating therapy and periodically thereafter.
  • Lactic acidosis risk: avoid in patients with severe renal or hepatic impairment.
  • Alcohol consumption: limit intake as it may increase lactate production.
  • Monitoring: regular measurement of blood glucose, HbA1c, and renal parameters.
  • Vitamin B12 levels: consider periodic testing during long‑term treatment.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformina Azevedos can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: can raise plasma metformin concentrations.
  • Chronic alcohol abuse: heightens the chance of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors or ARBs: require monitoring of renal function and electrolytes.

Frequently Asked Questions

Metformina Azevedos contains metformin hydrochloride and is indicated for the management of type 2 diabetes mellitus. It helps lower elevated blood glucose by reducing liver glucose production and improving insulin sensitivity in peripheral tissues.

Metformin works mainly by inhibiting mitochondrial complex I, which reduces hepatic gluconeogenesis. It also activates AMP‑activated protein kinase (AMPK), leading to increased glucose uptake by muscles and decreased fatty‑acid synthesis, thereby lowering blood glucose without stimulating insulin release.

The dose of Metformina Azevedos is individualized. A qualified prescriber determines the appropriate strength, frequency, and titration schedule based on the patient’s renal function, glycaemic targets, and overall clinical condition.

Metformin is generally not the first‑line therapy for pregnant women, but it may be used when benefits outweigh risks, especially in gestational diabetes. Limited data exist for breastfeeding; clinicians should assess the risk‑benefit ratio before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with sulfonylureas, metformin does not stimulate insulin secretion, reducing the risk of hypoglycaemia. It also promotes modest weight loss, whereas many alternatives may cause weight gain. Metformin is often used as first‑line therapy because of its efficacy, safety profile, and cardiovascular benefits.

Metformina Azevedos should be stored at ambient temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Metformina Azevedos is taken orally, usually with meals to minimise gastrointestinal upset. Tablets should be swallowed whole with a full glass of water; they are not intended for crushing, chewing, or dissolving unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, or in those with excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformina Azevedos is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or in those receiving iodinated contrast studies without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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