Product image of Metformina Bluefish (Metformin Hydrochloride) supplied by GNH India

Metformina Bluefish

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Bluefish (Metformin Hydrochloride)

Metformin, the active ingredient in Metformina Bluefish, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adults by improving blood glucose control. It belongs to the biguanide class and is administered orally, providing a convenient option for chronic management of hyperglycemia.

GNH India supplies Metformina Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmaceutical standards and is distributed to a broad network of healthcare providers.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Metformina Bluefish (metformin) is used in the management of disorders related to impaired glucose regulation.

  • Type 2 diabetes mellitus (monotherapy): lowers fasting plasma glucose and HbA1c levels.
  • Type 2 diabetes mellitus (combination therapy): enhances glycemic control when added to other antidiabetic agents.
  • Type 2 diabetes mellitus (insulin resistance): improves peripheral insulin sensitivity to reduce glucose production.

How It Works

  • Metformin acts primarily by inhibiting hepatic gluconeogenesis, thereby decreasing endogenous glucose production. It also increases peripheral glucose uptake in muscle and adipose tissue by enhancing insulin receptor signaling and activating AMP‑activated protein kinase (AMPK). The drug’s effect on the mitochondrial respiratory chain reduces cellular energy status, which further contributes to AMPK activation and the downstream inhibition of lipogenesis.

Side Effects

Metformina Bluefish may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Diarrhea: loose stools occurring especially after dose initiation.
  • Abdominal discomfort: cramping or pain in the stomach area.
  • Metallic taste: transient alteration in taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening buildup of lactate.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: significant elevation of liver enzymes or liver failure.

Precautions & Warnings

Before prescribing Metformina Bluefish, clinicians should consider several safety aspects to minimize risk.

  • Renal function: assess eGFR before initiating and periodically during therapy.
  • Hepatic function: evaluate liver enzymes to detect impairment.
  • Lactic acidosis risk: avoid in patients with hypoxia, severe infection, or uncontrolled heart failure.
  • Heart failure: use with caution in NYHA class III/IV conditions.
  • Vitamin B12: monitor levels during long‑term treatment as deficiency may develop.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformina Bluefish can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: increase risk of renal impairment and lactic acidosis.
  • Cimetidine: raises metformin plasma concentrations, heightening toxicity risk.
  • Alcohol: potentiates lactic acidosis, especially with chronic intake.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycemia.
  • Thiazide diuretics: can attenuate glucose‑lowering effect of metformin.

Frequently Asked Questions

Metformina Bluefish contains metformin, which is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus. It helps lower fasting glucose and HbA1c levels, either as a stand‑alone therapy or in combination with other antidiabetic agents.

Metformin reduces the liver’s production of glucose and increases the uptake of glucose by muscle and fat cells. It activates AMP‑activated protein kinase, which improves insulin sensitivity and decreases the amount of glucose released into the bloodstream.

The exact dose of Metformina Bluefish is individualized by the prescribing healthcare professional based on factors such as the patient’s renal function, glycemic targets, and response to therapy. No fixed dosing regimen is provided here.

The safety of metformin during pregnancy and lactation is not fully established. Physicians should evaluate the risk‑benefit profile for each patient and discuss potential alternatives or monitoring strategies if use is considered.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas, metformin does not stimulate insulin secretion, reducing the risk of hypoglycemia. Unlike insulin, it is taken orally and does not require injection. Its primary advantages are weight neutrality or modest loss and a low incidence of severe adverse events when used appropriately.

Metformina Bluefish should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare provider.

The most critical safety concerns include lactic acidosis, which is rare but life‑threatening, severe skin reactions such as Stevens‑Johnson syndrome, and significant liver enzyme elevations indicating hepatic dysfunction. Prompt medical attention is required if any of these symptoms appear.

Metformina Bluefish is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and those receiving radiographic studies with iodinated contrast agents without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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