Product image of Metformina + Sitagliptina Alter (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Metformina + Sitagliptina Alter

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Metformina + Sitagliptina Alter (Metformin Hydrochloride, Sitagliptin)

Metformin Hydrochloride, the active ingredient in Metformina + Sitagliptina Alter, is a biguanide presented as an oral tablet for oral use. It is used to improve glycemic control in adults with type 2 diabetes mellitus.
GNH India supplies Metformina + Sitagliptina Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alter S.A.

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Indications & Clinical Uses

Metformina + Sitagliptina Alter is indicated for the management of type 2 diabetes mellitus, acting on glucose metabolism pathways.

  • Type 2 diabetes mellitus: lowers fasting plasma glucose levels.
  • Type 2 diabetes mellitus: reduces hemoglobin A1c (HbA1c) concentrations.
  • Type 2 diabetes mellitus: improves post‑prandial glucose control.

How It Works

  • Metformin decreases hepatic gluconeogenesis and enhances peripheral insulin sensitivity, while sitagliptin inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), leading to increased endogenous incretin levels that stimulate glucose‑dependent insulin secretion and suppress glucagon release, together producing improved glycemic control.

Side Effects

The combination may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: increased bowel movements.
  • Headache: transient cranial discomfort.
  • Upper respiratory tract infection: mild cold‑like symptoms.
  • Abdominal discomfort: cramping or pain.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycemia: especially when combined with insulin or sulfonylureas.
  • Pancreatitis: inflammation of the pancreas.
  • Hepatic failure: impaired liver function.
  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin reaction.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for complications.

  • Renal impairment: assess kidney function and adjust dose if needed.
  • Hepatic impairment: use with caution; monitor liver enzymes.
  • Risk of lactic acidosis: avoid in patients with severe renal or hepatic disease.
  • Alcohol consumption: limit intake to reduce acidosis risk.
  • Pregnancy and lactation: safety not established; weigh benefits versus risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metformina + Sitagliptina Alter can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Other biguanides (e.g., phenformin): increased risk of lactic acidosis.
  • Iodinated contrast agents: may precipitate renal dysfunction and lactic acidosis.
  • Strong CYP3A4 inducers (e.g., rifampin): may reduce sitagliptin exposure.

Moderate Interactions (Monitor Closely)

  • Cimetidine: can raise metformin plasma concentrations.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics (especially thiazides): may affect renal clearance of metformin.

Frequently Asked Questions

Metformina + Sitagliptina Alter is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus, often when diet, exercise, and monotherapy with metformin are insufficient.

Metformin Hydrochloride reduces hepatic glucose production and increases peripheral insulin sensitivity, helping lower fasting and post‑prandial blood glucose levels.

Sitagliptin inhibits the enzyme DPP‑4, which raises endogenous incretin hormones, thereby enhancing glucose‑dependent insulin secretion and suppressing glucagon release.

The specific dose and dosing schedule are determined by the prescribing healthcare professional based on individual patient factors such as renal function, glycemic targets, and concomitant therapies.

Safety data in pregnancy and lactation are limited. The prescriber must evaluate the potential benefits against possible risks before initiating therapy in these populations.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with metformin alone, the addition of sitagliptin offers greater HbA1c reduction and better post‑prandial glucose control, while avoiding the weight gain often seen with sulfonylureas or insulin.

Store the tablets at ambient temperature, below 25 °C, in the original container, protected from moisture and light. Do not expose to excessive heat or humidity.

The medication is taken orally, usually with meals, as directed by the prescriber. Swallow the tablet whole with a full glass of water.

Serious risks include lactic acidosis, severe hypoglycemia (especially when combined with insulin or sulfonylureas), pancreatitis, and rare allergic reactions such as Stevens‑Johnson syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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