Product image of Metformina + Sitagliptina Ciclum (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Metformina + Sitagliptina Ciclum

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Metformina + Sitagliptina Ciclum (Metformin Hydrochloride, Sitagliptin)

Metformin Hydrochloride and Sitagliptin, the active ingredients in Metformina + Sitagliptina Ciclum, are a combination of a biguanide and a DPP‑4 inhibitor presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adults, helping to control blood glucose levels alongside diet and exercise.

GNH India supplies Metformina + Sitagliptina Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Metformina + Sitagliptina Ciclum is indicated for the management of type 2 diabetes mellitus, acting on glucose regulation pathways.

  • Type 2 diabetes mellitus: improves glycemic control when added to diet, exercise and other antidiabetic agents.
  • Inadequate control on metformin alone: provides additional glucose‑lowering effect as part of combination therapy.
  • Adults requiring combination therapy: offers a single‑pill option to simplify treatment regimens.

How It Works

  • Metformin decreases hepatic gluconeogenesis and enhances peripheral insulin sensitivity, while sitagliptin inhibits the dipeptidyl peptidase‑4 enzyme, raising endogenous incretin levels and promoting glucose‑dependent insulin secretion. Together, they lower blood glucose through complementary pathways without causing hypoglycaemia when used alone.

Side Effects

The following adverse reactions have been reported with the combination of metformin and sitagliptin.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhoea: frequent loose stools, usually transient.
  • Abdominal discomfort: cramping or pain.
  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection: symptoms of cold or flu.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycaemia: especially when combined with insulin or sulfonylureas.
  • Pancreatitis: acute inflammation of the pancreas.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic failure: marked liver dysfunction.
  • Renal impairment worsening: decline in kidney function.

Precautions & Warnings

When prescribing Metformina + Sitagliptina Ciclum, clinicians should consider several safety aspects.

  • Renal function assessment: avoid or adjust dose in patients with impaired renal function.
  • Hepatic disease monitoring: use with caution in liver disease due to lactic acidosis risk.
  • Risk of hypoglycaemia: monitor when combined with insulin or sulfonylureas.
  • Pregnancy and lactation: generally not recommended; evaluate risk‑benefit.
  • Contraindications: do not use in patients with known hypersensitivity to either component.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metformina + Sitagliptina Ciclum may interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate metformin‑associated lactic acidosis.
  • Insulin secretagogues (e.g., sulfonylureas): increase risk of severe hypoglycaemia.
  • Strong CYP3A4 inhibitors: may raise sitagliptin plasma levels.

Moderate Interactions (Monitor Closely)

  • Cimetidine: can increase sitagliptin exposure.
  • Diuretics and ACE inhibitors: may affect renal function, altering metformin clearance.
  • NSAIDs: can impair renal function, increasing metformin accumulation risk.
  • Warfarin: monitor INR as glycaemic changes may affect anticoagulation.

Frequently Asked Questions

Metformina + Sitagliptina Ciclum is a prescription oral medication used to improve blood glucose control in adults with type 2 diabetes mellitus, typically as an adjunct to diet, exercise and other antidiabetic agents.

Metformin Hydrochloride reduces hepatic glucose production and increases peripheral insulin sensitivity, helping lower fasting and post‑prandial blood glucose levels without directly stimulating insulin secretion.

The appropriate dose of Metformina + Sitagliptina Ciclum is determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function and response to therapy.

Metformina + Sitagliptina Ciclum is generally not recommended during pregnancy or lactation unless the potential benefit justifies the risk. Physicians should evaluate each case individually and discuss alternatives when possible.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with monotherapy, the metformin‑sitagliptin combo offers complementary mechanisms—metformin improves insulin sensitivity while sitagliptin enhances insulin secretion—resulting in greater HbA1c reduction without a substantial increase in hypoglycaemia risk, making it a convenient alternative to multiple separate tablets.

Metformina + Sitagliptina Ciclum should be stored below 25 °C in a dry place, kept in the original packaging to protect from moisture, and out of reach of children.

The medication is taken orally, usually once daily with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water.

The most serious risks include lactic acidosis, especially in patients with renal impairment, severe hypoglycaemia when combined with insulin or sulfonylureas, and rare cases of pancreatitis or severe skin reactions. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to metformin, sitagliptin or any excipients, those with severe renal or hepatic impairment, and individuals with a history of lactic acidosis should avoid this medication. Contraindications are outlined in the prescribing information.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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