Product image of Metformina + Sitagliptina Pentafarma (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Metformina + Sitagliptina Pentafarma

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Metformina + Sitagliptina Pentafarma (Metformin Hydrochloride, Sitagliptin)

Metformin hydrochloride, the active ingredient in Metformina + Sitagliptina Pentafarma, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adult patients, often in combination with diet and exercise. GNH India supplies Metformina + Sitagliptina Pentafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

Metformina + Sitagliptina Pentafarma is indicated for the management of type 2 diabetes mellitus and related glycemic control pathways.

  • Type 2 diabetes mellitus: lowers blood glucose and HbA1c levels.
  • Inadequate response to metformin alone: adds DPP‑4 inhibition to improve glycemic control.
  • Adjunct to diet and exercise: supports overall management of type 2 diabetes.

How It Works

  • Metformin decreases hepatic gluconeogenesis and enhances peripheral insulin sensitivity, while sitagliptin inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), leading to increased endogenous incretin hormones that stimulate glucose‑dependent insulin secretion and suppress glucagon release, together providing complementary glucose‑lowering effects.

Side Effects

The combination may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhea.
  • Metallic taste in the mouth.
  • Headache.
  • Decreased appetite.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic complication.
  • Severe hypoglycemia: especially when used with insulin or sulfonylureas.
  • Pancreatitis: inflammation of the pancreas requiring immediate medical attention.
  • Severe allergic reactions: such as rash, itching, swelling, or difficulty breathing.
  • Hepatic or renal failure: may be precipitated in susceptible individuals.

Precautions & Warnings

Use of this fixed‑dose combination requires careful clinical assessment.

  • Renal function: evaluate before initiation and monitor periodically.
  • Lactic acidosis risk: avoid in patients with significant hepatic impairment, severe infection, or hypoxia.
  • Hypoglycemia risk: exercise caution when combined with insulin or sulfonylureas.
  • Pregnancy and lactation: safety not established; prescribe only if benefits outweigh potential risks.
  • Vitamin B12 monitoring: long‑term metformin therapy may reduce absorption, requiring periodic assessment.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Metformina + Sitagliptina Pentafarma can interact with several medicines, necessitating monitoring.

Major Interactions (Avoid)

  • Insulin or sulfonylureas: increased risk of severe hypoglycemia.
  • Iodinated contrast agents: may precipitate renal dysfunction when combined with metformin.
  • Cimetidine: can raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of metformin.
  • ACE inhibitors or ARBs: require renal function monitoring.
  • Rifampin: may reduce sitagliptin plasma levels, potentially diminishing efficacy.

Frequently Asked Questions

Metformina + Sitagliptina Pentafarma is a prescription oral medication used to improve blood glucose control in adults with type 2 diabetes mellitus, typically as an adjunct to diet and exercise.

Metformin reduces hepatic glucose production and increases insulin sensitivity, while sitagliptin blocks the DPP‑4 enzyme, raising incretin levels that stimulate insulin release and suppress glucagon, together providing complementary glucose‑lowering effects.

The specific dose and dosing schedule are determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy.

Safety in pregnancy and lactation has not been established. The medication should only be used if the potential benefits justify the potential risks to the mother and fetus or infant.

Enquiries can be submitted via the product page on gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with metformin alone, the addition of sitagliptin offers greater HbA1c reduction without the weight gain associated with some other agents. It also provides an alternative to sulfonylureas or insulin for patients needing additional glucose control.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep out of reach of children.

The medication is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious risks include lactic acidosis, severe hypoglycemia (especially when combined with insulin or sulfonylureas), and pancreatitis. Patients should seek immediate medical attention if they experience symptoms such as rapid breathing, severe abdominal pain, or signs of an allergic reaction.

The combination is contraindicated in patients with known hypersensitivity to metformin, sitagliptin, or any excipients, as well as in individuals with severe renal impairment, acute or chronic metabolic acidosis, or a history of lactic acidosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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