Product image of Metformina + Sitagliptina Sandoz (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Metformina + Sitagliptina Sandoz

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Metformina + Sitagliptina Sandoz (Metformin Hydrochloride, Sitagliptin)

Metformin Hydrochloride and Sitagliptin, the active ingredient in Metformina + Sitagliptina Sandoz, is a Biguanide and DPP‑4 inhibitor presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults by improving glycemic control.

GNH India supplies Metformina + Sitagliptina Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Farmacêutica Lda.

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Indications & Clinical Uses

Metformina + Sitagliptina Sandoz is indicated for management of type 2 diabetes mellitus, targeting hyperglycemia through complementary mechanisms.

  • Type 2 diabetes mellitus: improves overall glycemic control when used with diet and exercise.
  • Combination therapy with other oral antidiabetics: provides additional glucose‑lowering effect.
  • Inadequate control on metformin alone: adds sitagliptin to achieve target HbA1c levels.

How It Works

  • Metformin decreases hepatic gluconeogenesis and enhances peripheral insulin sensitivity, while sitagliptin selectively inhibits dipeptidyl peptidase‑4 (DPP‑4), leading to increased endogenous incretin hormones (GLP‑1, GIP) that boost glucose‑dependent insulin secretion and suppress glucagon release, together producing improved blood glucose regulation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Headache: transient tension-type.
  • Mild hypoglycemia: especially when combined with insulin or sulfonylureas.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycemia: marked low blood glucose requiring assistance.
  • Pancreatitis: acute inflammation of the pancreas.
  • Severe allergic reactions: rash, angioedema, anaphylaxis.
  • Hepatic dysfunction: elevated liver enzymes.
  • Renal impairment: worsening kidney function.

Precautions & Warnings

Metformina + Sitagliptina Sandoz should be used with careful clinical monitoring.

  • Renal function: assess before initiation and monitor regularly.
  • Hepatic function: evaluate liver enzymes prior to therapy.
  • Cardiovascular disease: use cautiously in patients with heart failure.
  • Elderly patients: start at lower dose and monitor for accumulation.
  • Pregnancy and lactation: only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Metformina + Sitagliptina Sandoz may interact with several medicines.

Major Interactions (Avoid)

  • Severe renal impairment: increased risk of metformin accumulation.
  • Concomitant use with other DPP‑4 inhibitors: duplicate pharmacologic effect.
  • Co‑administration with insulin or sulfonylureas: heightened hypoglycemia risk.

Moderate Interactions (Monitor Closely)

  • Iodinated contrast studies: temporary discontinuation of metformin recommended.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise sitagliptin plasma levels.

Frequently Asked Questions

Metformina + Sitagliptina Sandoz is prescribed for adults with type 2 diabetes mellitus to improve blood glucose control when diet, exercise, and lifestyle measures alone are insufficient.

Metformin Hydrochloride reduces hepatic glucose production and increases peripheral insulin sensitivity, helping lower fasting and post‑prandial blood sugar levels.

The specific dose and dosing schedule are determined by the prescribing healthcare professional based on individual patient factors such as renal function, glycemic targets, and concomitant therapies.

Safety in pregnancy and lactation has not been fully established. It should only be used if the potential benefit outweighs any possible risk to the mother or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformina + Sitagliptina combines a Biguanide (metformin) with a DPP‑4 inhibitor (sitagliptin), offering dual mechanisms that can be more effective than metformin alone and avoid the weight gain associated with some other agents such as sulfonylureas.

Store the tablets at ambient temperature, below 25 °C, in the original container. Protect from moisture and direct sunlight to maintain product stability.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Patients should follow the prescribing clinician’s instructions regarding timing and any dose adjustments.

Serious risks include lactic acidosis (especially in patients with renal impairment), severe hypoglycemia when combined with insulin or sulfonylureas, and rare cases of pancreatitis or allergic reactions requiring immediate medical attention.

Patients with severe renal impairment, known hypersensitivity to metformin or sitagliptin, or those with a history of lactic acidosis should avoid this medication. Contraindications are confirmed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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