Product image of Metformina Stadafarma Stadafarma (Metformin Hydrochloride) supplied by GNH India

Metformina Stadafarma Stadafarma

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Stadafarma Stadafarma (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Stadafarma, is a biguanide presented as an oral dosage form for oral use. It is used to improve glycemic control in adults with type 2 diabetes mellitus, helping to lower fasting plasma glucose and HbA1c levels while also offering benefits in weight management.

GNH India supplies Metformina Stadafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and timely delivery across multiple regions globally.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Metformina Stadafarma (metformin) acts on glucose metabolism in type 2 diabetes and related insulin‑resistant conditions.

  • Type 2 diabetes mellitus: improves blood glucose control and reduces HbA1c.
  • Prediabetes: delays progression to overt diabetes by enhancing insulin sensitivity.
  • Polycystic ovary syndrome: reduces insulin resistance and may improve menstrual regularity.

How It Works

  • Metformin hydrochloride lowers hepatic gluconeogenesis and increases peripheral glucose uptake by activating AMP‑activated protein kinase (AMPK). This results in reduced liver glucose output, enhanced insulin‑mediated glucose utilization in muscle and adipose tissue, and modest weight loss. The drug does not stimulate insulin secretion, which limits risk of hypoglycaemia when used alone. Additionally, metformin improves lipid profiles and may have beneficial effects on endothelial function.

Side Effects

Metformina Stadafarma may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: frequent loose stools, especially during treatment initiation.
  • Metallic taste: transient alteration in taste perception.
  • Vitamin B12 deficiency: decreased absorption with long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: life‑threatening accumulation of lactate, requiring immediate medical attention.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: signs of liver injury including jaundice.

Precautions & Warnings

When prescribing Metformina Stadafarma, clinicians should consider several precautionary measures to minimise risk.

  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic status: evaluate liver function, as impairment may increase risk of lactic acidosis.
  • Risk of lactic acidosis: avoid use in patients with conditions predisposing to hypoxia or severe infection.
  • Concomitant drugs: review for agents that may affect metformin clearance, such as cimetidine.
  • Elderly patients: start with lower dose and monitor tolerance closely.
  • Store at room temperature: keep tablets in the original container, protect from moisture and heat.

Avoid Interactions

Metformina Stadafarma can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate lactic acidosis; discontinue metformin before imaging.
  • Cimetidine: reduces renal clearance, increasing metformin plasma levels.
  • Alcohol excess: heightens risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Thiazide diuretics: can increase risk of hyperglycaemia.

Frequently Asked Questions

Metformina Stadafarma contains metformin hydrochloride, which is prescribed primarily to improve blood glucose control in adults with type 2 diabetes mellitus. It helps lower fasting plasma glucose and HbA1c levels and may also aid modest weight reduction.

Metformin works by activating AMP‑activated protein kinase (AMPK), which suppresses hepatic glucose production and increases peripheral uptake of glucose in muscle and fat tissue. This dual action reduces overall blood sugar without stimulating insulin secretion.

The appropriate dose of Metformina Stadafarma is individualized by the prescribing healthcare professional based on factors such as the patient’s renal function, glycaemic targets, and tolerance. No fixed regimen is provided here.

Safety data for metformin in pregnancy are limited, and it is generally used only when the potential benefit outweighs the risk. Breastfeeding mothers should consult their physician, as metformin does pass into breast milk in small amounts.

To request Metformina Stadafarma, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas, metformin does not cause insulin‑mediated hypoglycaemia and often promotes modest weight loss. Unlike insulin, it is taken orally and acts primarily on hepatic glucose output. It is frequently used as first‑line therapy because of its efficacy, safety profile and cardiovascular benefits.

Metformina Stadafarma tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight and excessive heat to maintain product stability.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets are swallowed whole with a glass of water; the exact dosing schedule is determined by the prescriber.

The most critical adverse events include lactic acidosis, which is rare but life‑threatening, severe skin reactions such as Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should seek immediate medical attention if they experience unexplained fatigue, abdominal pain, rapid breathing, or skin blistering.

Metformina Stadafarma is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those with conditions that predispose to hypoxia such as severe heart failure or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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