Product image of Metformina Teva (Metformin Hydrochloride) supplied by GNH India

Metformina Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Teva, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus by improving blood glucose control in adult patients and belongs to the antidiabetic (oral hypoglycemic) therapeutic class. It is indicated for patients requiring long‑term glycaemic management.

GNH India supplies Metformina Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Metformina Teva (metformin) is used in the management of disorders related to impaired glucose metabolism.

  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c levels.
  • Prediabetes: helps delay progression to overt diabetes by enhancing insulin sensitivity.
  • Metabolic syndrome: contributes to weight management and improves lipid profile as part of comprehensive therapy.

How It Works

  • Metformin hydrochloride reduces hepatic gluconeogenesis, thereby decreasing the amount of glucose released into the bloodstream. It also increases peripheral insulin sensitivity, promoting glucose uptake in muscle and adipose tissue, and modestly lowers intestinal glucose absorption. These actions collectively lower fasting and post‑prandial blood glucose concentrations.

Side Effects

Metformina Teva may cause a range of adverse reactions, most of which are related to the gastrointestinal system or metabolic disturbances.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Diarrhoea: loose stools, often transient.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: altered taste perception.
  • Loss of appetite: reduced desire to eat.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic acidosis.
  • Severe hypoglycaemia: especially when combined with insulin or sulfonylureas.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Skin rash or hypersensitivity reactions.
  • Allergic reactions: including angio‑edema.

Precautions & Warnings

Before initiating Metformina Teva, several safety considerations should be reviewed.

  • Renal function assessment: evaluate eGFR and avoid use if eGFR <30 mL/min/1.73 m².
  • Hepatic function monitoring: use with caution in patients with liver disease.
  • Blood glucose monitoring: adjust dose based on fasting and post‑prandial glucose levels.
  • Concomitant alcohol intake: limit alcohol to reduce risk of lactic acidosis.
  • Elderly patients: start at lower dose and titrate slowly.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Metformina Teva can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk.
  • Cimetidine: can raise plasma metformin concentrations.
  • Alcohol excess: synergistic effect on lactate production leading to lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • Thiazide diuretics: may attenuate glucose‑lowering effect, requiring dose adjustment.

Frequently Asked Questions

Metformina Teva contains metformin hydrochloride, an oral biguanide indicated primarily for the treatment of type 2 diabetes mellitus. It helps lower elevated blood glucose by improving the body’s response to insulin and decreasing hepatic glucose production. It may also be prescribed for prediabetes or metabolic syndrome as part of a broader management plan.

Metformin acts mainly by inhibiting hepatic gluconeogenesis, which reduces the amount of glucose released into the bloodstream. It also increases peripheral insulin sensitivity, enhancing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal absorption of glucose. These combined actions lead to lower fasting and post‑prandial blood glucose levels.

The dosage of Metformina Teva is individualized by the prescribing healthcare professional based on the patient’s renal function, glycaemic targets, and tolerability. Typically, treatment starts with a low dose that is gradually increased, but the exact amount and frequency must be determined by the prescriber.

Metformina Teva is classified as pregnancy category unknown, but it is generally used only when the potential benefit outweighs potential risks. Limited data suggest it can be continued in pregnancy for women with type 2 diabetes under specialist supervision. It is excreted in breast milk in small amounts, so a risk‑benefit assessment is required before use while nursing.

To request Metformina Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements) and the necessary import documentation.

Compared with sulfonylureas, metformin (Metformina Teva) does not stimulate insulin secretion, so it carries a lower risk of hypoglycaemia. Unlike insulin, it is taken orally and does not require injection. Its weight‑neutral or modest weight‑loss effect contrasts with the weight gain often seen with thiazolidinediones. Overall, metformin is considered first‑line therapy for type 2 diabetes.

Metformina Teva tablets should be stored at ambient temperature, below 25 °C (77 °F). Keep them in the original blister or container, protect from moisture, heat and direct sunlight. Do not store in bathrooms or near kitchen appliances, and keep out of reach of children.

Metformina Teva is taken by mouth, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed by a healthcare professional. Consistent timing with respect to meals helps maintain stable drug absorption.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute cardiovascular events. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, abdominal discomfort, or unexplained fatigue develop.

Metformina Teva is contraindicated in patients with known hypersensitivity to metformin or any component of the formulation, in those with severe renal impairment (eGFR <30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in patients receiving iodinated contrast studies until renal function is re‑evaluated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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