Product image of Metformina Teva (Metformin Hydrochloride) supplied by GNH India

Metformina Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Teva, is a biguanide presented as an oral tablet for oral administration. It works to lower elevated blood glucose levels and is indicated for the long‑term management of type 2 diabetes mellitus in adult patients.

GNH India supplies Metformina Teva as a licensed, Good Distribution Practice‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets with consistent quality and regulatory assurance. The company ensures timely delivery and compliance with local import requirements.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

Metformina Teva (metformin hydrochloride) is used in the management of disorders related to glucose metabolism, primarily type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Prediabetes (impaired fasting glucose): delays progression to type 2 diabetes.
  • Polycystic ovary syndrome: helps restore ovulatory cycles and reduce insulin resistance.

How It Works

  • Metformin hydrochloride reduces hepatic gluconeogenesis, decreases intestinal glucose absorption, and enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue. These actions collectively lower fasting and post‑prandial blood glucose concentrations without stimulating insulin secretion.

Side Effects

Metformina Teva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, especially during treatment initiation.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration in taste perception.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: reduced absorption with long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: life‑threatening accumulation of lactate, especially in renal impairment.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Pancreatitis: inflammation of the pancreas.
  • Hypoglycemia: when combined with other glucose‑lowering agents.
  • Metabolic acidosis: rare but serious acid‑base disturbance.

Precautions & Warnings

Before initiating Metformina Teva, several safety considerations should be reviewed.

  • Renal function assessment: evaluate eGFR and avoid use in severe renal impairment.
  • Lactic acidosis risk: contraindicated in patients with significant hepatic disease or conditions predisposing to hypoxia.
  • Alcohol consumption: limit intake as it may increase the risk of lactic acidosis.
  • Surgery or radiologic contrast procedures: withhold metformin before and after the procedure until renal function is confirmed.
  • Pregnancy and lactation: discuss potential risks and benefits with a healthcare professional.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformina Teva can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may cause acute kidney injury; discontinue metformin before and for 48 hours after exposure.
  • Cimetidine: can increase metformin plasma concentrations, raising the risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers, diuretics, ACE inhibitors: may impair renal function, necessitating renal monitoring.
  • Alcohol: potentiates the risk of lactic acidosis.
  • Other antidiabetic agents (e.g., sulfonylureas, insulin): increase the likelihood of hypoglycemia.
  • Corticosteroids: may elevate blood glucose, requiring dose adjustments.

Frequently Asked Questions

Metformina Teva contains metformin hydrochloride, a biguanide that is prescribed to improve blood‑sugar control in adults with type 2 diabetes mellitus. It helps lower fasting and post‑prandial glucose levels and is part of long‑term diabetes management strategies.

Metformin Hydrochloride acts primarily by inhibiting hepatic glucose production, reducing intestinal glucose absorption, and enhancing peripheral insulin sensitivity. These combined effects lower circulating glucose without stimulating insulin release, making it effective for patients with insulin resistance.

The appropriate dose of Metformina Teva is determined individually by a prescriber based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made according to therapeutic goals and tolerability, and patients should follow the prescribing physician’s instructions.

Safety data for metformin during pregnancy and lactation are limited. It may be used when the potential benefit justifies the potential risk, but the decision should be made by a healthcare professional. Breastfeeding mothers should discuss possible exposure with their clinician.

To order Metformina Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metformina Teva (metformin) differs from sulfonylureas, DPP‑4 inhibitors or insulin by not stimulating insulin secretion, which reduces the risk of hypoglycemia. It also promotes modest weight loss and has a well‑established cardiovascular safety profile, making it a first‑line option in many treatment guidelines.

Metformina Teva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Metformina Teva is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or hypoxia. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformina Teva is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving radiographic contrast studies that may affect kidney function. Clinicians should assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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