Product image of Metformina Tevagen (Metformin) supplied by GNH India

Metformina Tevagen

Active Ingredient:
Metformin
Origin:
EU

Metformina Tevagen (Metformin)

Metformin, the active ingredient in Metformina Tevagen, is a biguanide presented as a unknown/unknown for oral use. It treats type 2 diabetes mellitus and is also used off‑label for gestational diabetes and polycystic ovary syndrome in appropriate patients.

GNH India supplies Metformina Tevagen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

1
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Indications & Clinical Uses

Metformin is an oral antidiabetic agent used to improve glycaemic control in several metabolic conditions.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose and reduces HbA1c.
  • Gestational diabetes (off‑label): helps maintain maternal glucose levels within target ranges.
  • Polycystic ovary syndrome (off‑label): may improve insulin resistance and regularise menstrual cycles.

How It Works

  • Metformin primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK), which reduces glucose output. It also decreases intestinal glucose absorption and enhances peripheral insulin sensitivity, facilitating greater glucose uptake by muscle and adipose tissue without stimulating insulin secretion.

Side Effects

Metformin is associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: loose stools occurring especially after treatment initiation.
  • Metallic taste: transient alteration in taste perception.
  • Decreased vitamin B12 levels: may develop with long‑term therapy.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic disturbance.
  • Severe hypoglycaemia: usually when combined with insulin or secretagogues.
  • Hepatic dysfunction: elevated liver enzymes or hepatic failure.
  • Skin reactions: rash, urticaria, or Stevens‑Johnson syndrome.
  • Pancreatitis: inflammation of the pancreas reported in isolated cases.
  • Anemia: due to reduced red blood cell production.

Precautions & Warnings

Before initiating Metformina Tevagen, clinicians should consider several safety factors.

  • Monitor renal function: adjust or discontinue in moderate to severe renal impairment.
  • Assess hepatic status: avoid in patients with significant liver disease.
  • Evaluate risk of lactic acidosis: contraindicated in hypoxia, heart failure, or severe infection.
  • Review concomitant alcohol use: excessive intake increases acidosis risk.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Metformina Tevagen can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast media: may precipitate lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol abuse: heightens risk of metabolic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycaemia.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors: require renal function monitoring when combined.
  • NSAIDs: may impair renal clearance of metformin.

Frequently Asked Questions

Metformina Tevagen contains metformin, a biguanide oral antidiabetic that is prescribed to improve blood‑sugar control in adults with type 2 diabetes mellitus. It may also be used off‑label for gestational diabetes and polycystic ovary syndrome when clinically appropriate.

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and enhances peripheral insulin sensitivity. These actions are mediated mainly through activation of AMP‑activated protein kinase (AMPK), which helps lower circulating glucose without stimulating insulin release.

The specific dose of Metformina Tevagen is determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Metformina Tevagen is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy when benefits outweigh risks, but clinicians should evaluate each case. Breastfeeding mothers should discuss potential exposure with their doctor.

To request Metformina Tevagen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often first‑line therapy for type 2 diabetes because it improves insulin sensitivity without causing weight gain and has a low risk of hypoglycaemia when used alone. Compared with sulfonylureas or insulin, metformin does not stimulate insulin release, making it safer in many patients, though combination therapy may be needed for optimal control.

Metformina Tevagen should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not store in humid or excessively hot environments.

Metformina Tevagen is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets (or other oral form) should be swallowed whole with a full glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, hypoxia, or excessive alcohol intake. Other serious concerns include severe hypoglycaemia when combined with insulin or secretagogues, and rare cases of hepatic dysfunction.

Metformina Tevagen is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or in those with conditions that predispose to hypoxia such as severe heart failure or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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