Product image of Metformina + Vildagliptina (Metformin Hydrochloride, Vildagliptin) supplied by GNH India

Metformina + Vildagliptina

Active Ingredient:
Metformin Hydrochloride, Vildagliptin
Origin:
EU

Metformina + Vildagliptina (Metformin Hydrochloride, Vildagliptin)

Metformin Hydrochloride, the active ingredient in Metformina + Vildagliptina, is a biguanide/DPP‑4 inhibitor presented as a tablet for oral use. It helps lower elevated blood glucose levels in adults diagnosed with type 2 diabetes mellitus by improving insulin sensitivity and enhancing insulin secretion.

GNH India supplies Metformina + Vildagliptina as a licensed, GDP‑compliant product to hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory conformity for international markets through a robust supply chain and dedicated technical support.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Metformina + Vildagliptina is indicated for the management of type 2 diabetes mellitus, a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion.

  • Type 2 diabetes mellitus: improves glycemic control in adults when combined therapy is required.
  • Inadequate response to metformin monotherapy: adds DPP‑4 inhibition to achieve additional glucose lowering.
  • Patients needing a fixed‑dose combination: simplifies regimen and may enhance adherence.

How It Works

  • Metformina + Vildagliptina combines metformin, which suppresses hepatic gluconeogenesis and increases peripheral insulin sensitivity, with vildagliptin, a reversible inhibitor of dipeptidyl peptidase‑4 (DPP‑4). By blocking DPP‑4, vildagliptin prolongs the activity of endogenous incretin hormones (GLP‑1 and GIP), leading to glucose‑dependent enhancement of insulin secretion and suppression of glucagon release. The complementary actions address both insulin resistance and deficient insulin response.

Side Effects

The combination may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea, abdominal discomfort, or dyspepsia: mild gastrointestinal upset that may improve with continued therapy.
  • Diarrhea: loose stools occurring intermittently, usually self‑limiting.
  • Headache: mild to moderate intensity, often transient.

Serious or Rare Side Effects

  • Lactic acidosis: rare metabolic emergency characterized by elevated lactate, requiring immediate medical attention.
  • Severe hypoglycemia: pronounced low blood glucose, especially when used with insulin or sulfonylureas, presenting with confusion, sweating, or loss of consciousness.
  • Acute pancreatitis: inflammation of the pancreas presenting with severe abdominal pain, nausea, and elevated pancreatic enzymes.

Precautions & Warnings

When prescribing Metformina + Vildagliptina, clinicians should consider several precautionary measures to ensure safe use.

  • Renal function: assess creatinine clearance before initiation and periodically, as metformin accumulation can increase lactic acidosis risk.
  • Hepatic impairment: use with caution in patients with liver disease due to altered drug metabolism.
  • Cardiovascular disease: monitor for heart failure, as metformin is contraindicated in unstable conditions.
  • Concomitant medications: review for drugs that may affect renal clearance or increase hypoglycemia risk.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metformina + Vildagliptina may interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Insulin or sulfonylureas: increased risk of severe hypoglycemia.
  • Iodinated contrast agents: may precipitate renal impairment, requiring temporary discontinuation of metformin.
  • Cimetidine: can raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics (thiazides): may enhance hyperglycemic effect of metformin.
  • Corticosteroids: can reduce glucose‑lowering efficacy, necessitating dose adjustment.
  • Anticoagulants (e.g., warfarin): vildagliptin may affect INR, requiring monitoring.

Frequently Asked Questions

Metformina + Vildagliptina is prescribed to adults with type 2 diabetes mellitus to improve overall blood‑glucose control. It combines two mechanisms—reduction of hepatic glucose production and enhancement of insulin secretion—to achieve better glycaemic outcomes when diet, exercise, or single‑agent therapy are insufficient.

Metformin Hydrochloride lowers glucose by inhibiting hepatic gluconeogenesis and increasing peripheral insulin sensitivity. In the fixed‑dose combination, it works alongside vildagliptin, which preserves incretin hormones, creating a complementary effect that addresses both insulin resistance and inadequate insulin release.

The appropriate dose is individualized by the prescribing healthcare professional based on the patient’s renal function, glycaemic targets, and prior response to therapy. No standard dosing regimen is provided here; the prescriber sets the exact amount and schedule.

Safety data in pregnancy and lactation are limited, and the product is generally not recommended unless the potential benefit justifies the potential risk to the fetus or infant. Clinicians should evaluate each case carefully and consider alternative treatments when possible.

To place an enquiry, visit the product page on gnhindia.com, enter the required quantity, and submit the request. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with metformin alone, the addition of vildagliptin offers extra glucose‑lowering through incretin preservation, often achieving better HbA1c reduction without the weight gain seen with some sulfonylureas. Unlike insulin, it does not require injection, and it provides a fixed‑dose option that can simplify treatment regimens.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with meals to reduce gastrointestinal discomfort. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare provider.

The most critical adverse events include lactic acidosis (a rare but life‑threatening metabolic condition), severe hypoglycaemia—especially when combined with insulin or sulfonylureas—and acute pancreatitis. Prompt medical attention is required if any of these symptoms arise.

Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), active liver disease, a history of lactic acidosis, or known hypersensitivity to metformin, vildagliptin, or any excipients should avoid this medication. It is also contraindicated in unstable heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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