Product image of Metformina + Vildagliptina Pentafarma (Metformin Hydrochloride, Vildagliptin) supplied by GNH India

Metformina + Vildagliptina Pentafarma

Active Ingredient:
Metformin Hydrochloride, Vildagliptin
Origin:
EU

Metformina + Vildagliptina Pentafarma (Metformin Hydrochloride, Vildagliptin)

Metformin hydrochloride, the active ingredient in Metformina + Vildagliptina Pentafarma, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adult patients by improving glycemic control.
GNH India supplies Metformina + Vildagliptina Pentafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

Metformina + Vildagliptina Pentafarma is used in the management of type 2 diabetes mellitus, a chronic metabolic disorder requiring long‑term glucose‑lowering therapy.

  • Type 2 diabetes mellitus: improves overall glycemic control when added to diet and exercise.
  • Inadequate control on metformin alone: provides additional glucose‑lowering effect through DPP‑4 inhibition.
  • Patients needing combination therapy: simplifies regimen by combining a biguanide with a DPP‑4 inhibitor in a single tablet.

How It Works

  • Metformin reduces hepatic gluconeogenesis and increases peripheral insulin sensitivity, while vildagliptin inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), leading to higher endogenous incretin levels (GLP‑1 and GIP). The elevated incretins enhance glucose‑dependent insulin secretion and suppress glucagon release, together producing a complementary reduction in blood glucose.

Side Effects

The most frequently reported reactions are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal discomfort: cramping or pain.
  • Headache: mild tension‑type headache.
  • Dizziness: light‑headed sensation.
  • Metallic taste: altered taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycaemia: especially when combined with insulin or sulfonylureas.
  • Acute pancreatitis: sudden abdominal pain with elevated enzymes.
  • Hepatic failure: marked liver enzyme elevation.
  • Anaphylactic reaction: severe allergic response requiring emergency care.

Precautions & Warnings

Metformina + Vildagliptina Pentafarma requires careful patient assessment before initiation.

  • Renal function: assess eGFR; avoid in severe renal impairment.
  • Hepatic disease: use with caution; monitor liver enzymes.
  • Lactic acidosis risk: discontinue if patient develops hypoxia, sepsis, or acute heart failure.
  • Concomitant hypoglycaemic agents: monitor for low blood glucose.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Drug‑drug interactions may affect efficacy or safety of Metformina + Vildagliptina Pentafarma.

Major Interactions (Avoid)

  • Severe renal failure: increased risk of metformin accumulation.
  • Hepatic failure: heightened lactic acidosis potential.
  • Alcohol abuse: potentiates metformin‑related lactic acidosis.
  • Concurrent use of other biguanides: additive risk of toxicity.
  • Iodinated contrast agents: may precipitate acute renal injury.

Moderate Interactions (Monitor Closely)

  • Sulfonylureas or insulin: increased hypoglycaemia risk.
  • Diuretics (especially thiazides): may reduce renal clearance.
  • ACE inhibitors or ARBs: monitor renal function and electrolytes.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • CYP450‑modulating drugs: observe for altered vildagliptin levels.

Frequently Asked Questions

Metformina + Vildagliptina Pentafarma is prescribed to improve blood‑glucose control in adults with type 2 diabetes mellitus, particularly when diet, exercise, and metformin alone are insufficient.

Metformin lowers glucose production by the liver and enhances insulin sensitivity in muscle and fat tissue, helping the body use glucose more efficiently.

The exact dose and dosing schedule are determined by the prescribing clinician based on the patient’s renal function, glycaemic targets, and overall treatment plan.

Safety in pregnancy and lactation has not been established. The prescriber must weigh potential benefits against possible risks before use in these populations.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with metformin alone, the addition of vildagliptin provides greater HbA1c reduction without the weight gain often seen with sulfonylureas or insulin, offering a convenient fixed‑dose option for patients needing dual therapy.

Store the tablets at ambient temperature, below 25 °C, in the original blister pack or container, protected from moisture and direct sunlight.

Metformina + Vildagliptina Pentafarma is taken orally, usually with meals to reduce gastrointestinal discomfort, as directed by the healthcare professional.

The most serious risks include lactic acidosis, severe hypoglycaemia (especially when combined with insulin or sulfonylureas), and acute pancreatitis. Patients should seek immediate medical attention if they experience unexplained muscle pain, rapid breathing, severe abdominal pain, or signs of low blood sugar.

Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), active liver disease, a history of lactic acidosis, or known hypersensitivity to metformin or vildagliptin should avoid this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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