Product image of Metformina Zentiva (Metformin Hydrochloride) supplied by GNH India

Metformina Zentiva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformina Zentiva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformina Zentiva, is a biguanide presented as an oral tablet for oral use. It is employed to lower elevated blood glucose levels in adults with type 2 diabetes mellitus and is also indicated for gestational diabetes management, and may be used as part of a comprehensive lifestyle and dietary plan.

GNH India supplies Metformina Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

Metformina Zentiva (metformin) is used to improve glycemic control in disorders of glucose metabolism.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels.
  • Gestational diabetes mellitus: helps achieve target glucose levels during pregnancy.
  • Prediabetes (impaired glucose tolerance): delays progression to overt diabetes when combined with lifestyle measures.

How It Works

  • Metformin Hydrochloride reduces hepatic gluconeogenesis and increases peripheral insulin sensitivity by activating AMP‑activated protein kinase (AMPK). This leads to decreased glucose production in the liver and enhanced glucose uptake in muscle and adipose tissue, improving overall glycemic control without directly stimulating insulin secretion.

Side Effects

Metformina Zentiva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: transient alteration of taste.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: reduced absorption over long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: life‑threatening metabolic acidosis.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes.
  • Hypoglycemia: when combined with other glucose‑lowering agents.
  • Anemia: rare hematologic effect.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Metformina Zentiva should be used with attention to patient‑specific risk factors and clinical monitoring.

  • Renal function: assess eGFR before initiation and periodically thereafter.
  • Hepatic function: avoid in patients with significant liver disease.
  • Lactic acidosis risk: discontinue before major surgery or iodinated contrast studies.
  • Alcohol consumption: limit intake to reduce acidosis risk.
  • Pregnancy and breastfeeding: evaluate benefits versus risks with a healthcare professional.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformina Zentiva can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Iodinated contrast media: may precipitate lactic acidosis.
  • Alcohol: increases risk of metabolic acidosis.
  • Cimetidine: can raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • ACE inhibitors/ARBs: monitor renal function and potassium levels.
  • Other antidiabetic agents: adjust dose to avoid hypoglycemia.
  • Thyroid hormones: may alter glucose metabolism.

Frequently Asked Questions

Metformina Zentiva contains metformin hydrochloride and is prescribed to lower elevated blood glucose in adults with type 2 diabetes mellitus, to manage gestational diabetes, and to help delay progression from prediabetes to diabetes when combined with lifestyle changes.

Metformin works primarily by activating AMP‑activated protein kinase (AMPK), which suppresses hepatic glucose production and improves insulin‑mediated glucose uptake in muscle and fat tissue, thereby reducing overall blood sugar levels without stimulating insulin secretion.

The dosage of Metformina Zentiva is individualized by the prescribing clinician based on the patient’s glycemic targets, renal function, and tolerability. The prescriber determines the appropriate strength, frequency, and titration schedule.

Metformina Zentiva may be used during pregnancy or lactation only when the potential benefit outweighs the risk. Healthcare providers should evaluate each case, as data are limited and alternative therapies may be preferred.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformina Zentiva belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, and SGLT2 inhibitors. It primarily reduces hepatic glucose output and improves insulin sensitivity, whereas other classes may increase insulin secretion, inhibit glucose reabsorption, or affect incretin pathways.

Metformina Zentiva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Metformina Zentiva is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a full glass of water; they should not be crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse effect is lactic acidosis, a rare but potentially fatal metabolic disturbance. Other serious concerns include severe skin reactions such as Stevens‑Johnson syndrome, hepatic dysfunction, and, in rare cases, pancreatitis.

Metformina Zentiva is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in those receiving iodinated contrast agents for imaging without appropriate interruption of therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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