Product image of Metformine Accord (Metformin Hydrochloride) supplied by GNH India

Metformine Accord

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Accord (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformine Accord, is a Biguanide presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults by improving blood‑glucose control.
GNH India supplies Metformine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare France Sas

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Indications & Clinical Uses

Metformine Accord is used in the management of the metabolic disorder that affects glucose regulation.

  • Type 2 diabetes mellitus: helps lower elevated blood glucose levels and improves glycaemic control.

How It Works

  • Metformin Hydrochloride reduces hepatic gluconeogenesis, decreases intestinal absorption of glucose, and enhances peripheral insulin sensitivity. By activating AMP‑activated protein kinase (AMPK), it modulates key metabolic pathways that lower circulating glucose without stimulating insulin secretion.

Side Effects

Metformine Accord may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Metallic taste: transient alteration of taste perception.
  • Weight loss: modest reduction in body weight.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening accumulation of lactate.
  • Vitamin B12 deficiency: may develop with long‑term therapy.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: abnormal liver enzymes in susceptible individuals.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: ensure adequate kidney clearance before prescribing.
  • Hepatic status review: avoid use in patients with significant liver disease.
  • Cardiovascular risk: monitor for signs of heart failure.
  • Pregnancy and lactation: weigh potential benefits against unknown risks.
  • Concomitant alcohol use: limit intake to reduce lactic acidosis risk.
  • Store at ambient temperature: keep below 25°C in the original container, protected from moisture.

Avoid Interactions

Metformine Accord can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure.
  • Cimetidine: can increase metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): raise risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of metformin.
  • Beta‑blockers: can mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal function when combined.

Frequently Asked Questions

Metformine Accord contains metformin hydrochloride, which is prescribed to lower high blood‑sugar levels in adults with type 2 diabetes mellitus. It helps improve glycaemic control when used as part of a comprehensive diabetes management plan that includes diet and exercise.

Metformin works primarily by inhibiting hepatic glucose production, reducing the amount of glucose released into the bloodstream. It also decreases intestinal glucose absorption and enhances the sensitivity of muscle cells to insulin, allowing more efficient uptake of glucose from the blood.

The exact dose of Metformine Accord is determined by the prescribing healthcare professional based on the individual’s medical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metformin during pregnancy or lactation is not fully established. Healthcare providers weigh potential benefits against possible risks before prescribing it to pregnant or nursing women. Women should discuss their specific situation with a qualified clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformine Accord belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors. Unlike insulin‑secretagogues, metformin does not stimulate insulin release, reducing the risk of hypoglycaemia. Its primary actions are on hepatic glucose output and insulin sensitivity.

Metformine Accord should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metformine Accord is taken orally, usually with meals to minimise gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

The most serious potential risk is lactic acidosis, a rare but life‑threatening condition characterized by buildup of lactate in the blood. Signs include rapid breathing, muscle pain, abdominal discomfort, and unusual fatigue. Prompt medical attention is required if these symptoms appear.

Metformine Accord is contraindicated in individuals with severe renal impairment, acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those who have experienced lactic acidosis while on metformin therapy. Patients with these conditions should discuss alternative treatments with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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