Product image of Metformine Eg (Metformin Hydrochloride) supplied by GNH India

Metformine Eg

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Eg (Metformin Hydrochloride)

Metformin, the active ingredient in Metformine Eg, is a biguanide presented as an oral formulation for oral use. It is used to improve blood glucose control in patients with type 2 diabetes mellitus.
GNH India supplies Metformine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg Labo Laboratoires Eurogenerics

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Indications & Clinical Uses

  • Metformine Eg is indicated for conditions affecting glucose metabolism and insulin sensitivity.
  • Type 2 diabetes mellitus: lowers fasting plasma glucose and HbA1c levels.
  • Impaired glucose tolerance: helps delay progression to overt diabetes.
  • Polycystic ovary syndrome: reduces insulin resistance and associated hyperandrogenism.

How It Works

  • Metformin primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK), which reduces glucose production. It also enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal glucose absorption, collectively leading to lower blood glucose concentrations.

Side Effects

Metformine Eg may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: transient gastrointestinal upset.
  • Diarrhea: loose stools, often early in therapy.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: altered taste perception.
  • Loss of appetite: reduced food intake.
  • Flatulence: increased gas production.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycemia: when combined with insulin or secretagogues.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hepatic dysfunction: elevated liver enzymes.
  • Skin reactions: rash or Stevens‑Johnson syndrome.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

  • Before initiating Metformine Eg, certain safety considerations should be observed.
  • Renal function: assess eGFR and avoid use if severely impaired.
  • Lactic acidosis risk: contraindicated in hepatic failure or severe infection.
  • Alcohol consumption: limit intake to reduce acidosis risk.
  • Surgery or contrast studies: withhold metformin temporarily.
  • Pregnancy: discuss potential risks with the prescriber.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metformine Eg can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Iodinated contrast agents: increase risk of renal failure and lactic acidosis.
  • Cimetidine: raises metformin plasma concentrations.
  • Acute alcohol intoxication: heightens lactic acidosis risk.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Thiazide diuretics: can elevate blood glucose levels.
  • ACE inhibitors/ARBs: may affect renal function, requiring monitoring.

Frequently Asked Questions

Metformine Eg contains metformin hydrochloride and is used to improve glycemic control in adults with type 2 diabetes mellitus. It may also be prescribed for impaired glucose tolerance and polycystic ovary syndrome to enhance insulin sensitivity.

Metformin reduces hepatic glucose production by activating AMP‑activated protein kinase, increases peripheral glucose uptake, and modestly decreases intestinal glucose absorption. These actions together lower blood glucose levels without stimulating insulin secretion.

The dose of Metformine Eg is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule.

The safety of metformin in pregnancy is not fully established; it should only be used if the potential benefit justifies the potential risk. Metformin is excreted in breast milk, so a healthcare professional should evaluate the risk‑benefit ratio for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Metformine Eg belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, and SGLT2 inhibitors. Unlike insulin‑secretagogues, metformin does not cause hypoglycemia when used alone and has a favorable effect on weight and cardiovascular risk profiles.

Metformine Eg should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.

Metformine Eg is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water; they are not intended for crushing or chewing unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with renal or hepatic impairment, severe infection, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformine Eg is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving radiographic contrast studies that may affect kidney function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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