Product image of Metformine Hcl 1a Pharma (Metformin Hydrochloride) supplied by GNH India

Metformine Hcl 1a Pharma

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Hcl 1a Pharma (Metformin Hydrochloride)

Metformin hydrochloride, the active ingredient in Metformine Hcl 1a Pharma, is a biguanide presented as an oral dosage form for oral use. It is employed to lower elevated blood glucose levels in adults with type 2 diabetes mellitus and is often part of a comprehensive diabetes management plan that includes diet and exercise.

GNH India supplies Metformine Hcl 1a Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Metformine Hcl 1a Pharma is used in the management of disorders related to impaired glucose metabolism.

  • Type 2 diabetes mellitus: improves glycaemic control and reduces HbA1c levels.
  • Prediabetes: helps delay progression to overt diabetes when combined with lifestyle measures.
  • Polycystic ovary syndrome: reduces insulin resistance and may improve menstrual regularity.

How It Works

  • Metformin hydrochloride reduces hepatic gluconeogenesis, decreases intestinal glucose absorption, and enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue. These actions collectively lower fasting and post‑prandial blood glucose without stimulating insulin secretion.

Side Effects

Metformine Hcl 1a Pharma may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhoea: frequent loose stools, especially at treatment initiation.
  • Metallic taste: transient alteration in taste perception.
  • Abdominal discomfort: cramping or bloating.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: gradual decrease with long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Hypoglycaemia: uncommon when used alone, more likely with concomitant insulin.
  • Renal impairment worsening: due to accumulation of the drug.
  • Anemia: due to reduced red blood cell production.

Precautions & Warnings

Before initiating therapy, several safety considerations should be observed.

  • Renal function assessment: ensure adequate glomerular filtration rate before prescribing.
  • Hepatic function monitoring: avoid use in patients with significant liver disease.
  • Cardiovascular status: use cautiously in heart failure due to risk of lactic acidosis.
  • Vitamin B12 monitoring: periodic testing recommended for long‑term therapy.
  • Avoid in acute metabolic acidosis: contraindicated in conditions that predispose to lactic acidosis.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Metformine Hcl 1a Pharma can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol: enhances risk of lactic acidosis.
  • Rifampicin: reduces metformin effectiveness.
  • Certain antiretrovirals: may increase metformin levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemic symptoms.
  • Diuretics: can affect renal clearance of metformin.
  • ACE inhibitors/ARBs: monitor renal function and potassium.
  • Warfarin: occasional alteration of INR values.
  • Thyroid hormones: may require dose adjustments of antidiabetic therapy.

Frequently Asked Questions

Metformine Hcl 1a Pharma contains metformin hydrochloride and is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus. It may also be used in prediabetes and polycystic ovary syndrome to address insulin resistance.

Metformin acts primarily by inhibiting hepatic glucose production, reducing intestinal glucose absorption, and increasing peripheral insulin sensitivity. These combined effects lower fasting and post‑prandial blood glucose without stimulating insulin release.

The appropriate dose is determined by the prescribing healthcare professional based on individual patient factors such as renal function, glycaemic targets, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metformin during pregnancy is not fully established, and it is classified as pregnancy category unknown. It may be used if the potential benefit outweighs the risk, but clinicians usually evaluate alternatives. Metformin is excreted in breast milk; breastfeeding mothers should discuss risks with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often first‑line therapy for type 2 diabetes because of its efficacy, low risk of hypoglycaemia and favourable impact on weight. Compared with sulfonylureas, it does not cause insulin spikes, and unlike insulin it is taken orally. Newer agents such as SGLT2 inhibitors or GLP‑1 receptor agonists may be added for additional benefit, but metformin remains a cornerstone of therapy.

Metformine Hcl 1a Pharma should be stored at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

The medication is taken orally, usually with meals to minimise gastrointestinal upset. Tablets should be swallowed whole with a full glass of water. The exact timing and frequency are determined by the prescriber.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformine Hcl 1a Pharma is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving iodinated contrast studies without appropriate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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